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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">persmed</journal-id><journal-title-group><journal-title xml:lang="ru">Российский журнал персонализированной медицины</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal for Personalized Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2782-3806</issn><issn pub-type="epub">2782-3814</issn><publisher><publisher-name>ФОНД АЛМАЗОВА</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18705/2782-3806-2022-2-2-46-53</article-id><article-id custom-type="elpub" pub-id-type="custom">persmed-16</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWERS</subject></subj-group></article-categories><title-group><article-title>Синдром обструктивного апноэ сна и сердечно-сосудистые заболевания: от диагностики к персонализированной терапии (часть 1)</article-title><trans-title-group xml:lang="en"><trans-title>Obstructive sleep apnea syndrome and cardiovascular diseases: from diagnosis to personalized therapy (part 1)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7293-1144</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ионин</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ionin</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Валерий Александрович Ионин, к. м. н., доцент, старший научный сотрудник</p><p>Федеральное государственное бюджетное образовательное учреждение высшего образования «Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова»</p><p>кафедра терапии факультетской с курсом эндокринологии,кардиологии с клиникой им. акад. Г. Ф. Ланга</p><p>тел.: +79213727684</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Valery A. Ionin, PhD, Associate Professor, Senior Researcher Federal State Budgetary Educational Institution of Higher Education "First St. Petersburg State Medical University named after Academician I. P. Pavlov"</p><p>Department of faculty therapy with a course of endocrinology,cardiology with a clinic named after acad. G. F. Lang</p><p>phone: +79213727684</p><p>Saint-Petersburg</p></bio><email xlink:type="simple">ionin.v.a@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8479-0331</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Павлова</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Pavlova</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Виктория Александровна Павлова, клинический ординатор</p><p>Федеральное государственное бюджетное образовательное учреждение высшего образования «Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова»</p><p>кафедра терапии факультетской с курсом эндокринологии, кардиологии с клиникой им. акад. Г. Ф. Ланга</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Victoria A. Pavlova, Clinical Resident</p><p>Federal State Budgetary Educational Institution of Higher Education "First St. Petersburg State Medical University named after Academician I. P. Pavlov"</p><p>Department of faculty therapy with a course of endocrinology, cardiology with a clinic named after acad. G. F. Lang</p><p>Saint-Petersburg</p></bio><email xlink:type="simple">ilingina@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8788-0076</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Баранова</surname><given-names>Е. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Baranova</surname><given-names>E. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Елена Ивановна Баранова, д. м. н., профессор, , директор, заведующий</p><p>Федеральное государственное бюджетное образовательное учреждение высшего образования «Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова» ; Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова»</p><p>кафедра терапии факультетской с курсом эндокринологии, кардиологии с клиникой им. акад. Г. Ф. Ланга</p><p>Институт эндокринологии</p><p>НИЛ метаболического синдрома</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Elena I. Baranova, MD, Professor, , Director, Head</p><p>Federal State Budgetary Educational Institution of Higher Education "First St. Petersburg State Medical University named after Academician I. P. Pavlov"; Federal State Budgetary Institution "National Medical Research Center named after V. A. Almazov"</p><p>Department of faculty therapy with a course of endocrinology, cardiology with a clinic named after acad. G. F. Lang</p><p>Institute of Endocrinology</p><p>NILE metabolic syndrome</p><p>Saint-Petersburg</p></bio><email xlink:type="simple">baranova.grant2015@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Министерство здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pavlov St-Petersburg State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Министерство здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pavlov St-Petersburg State Medical University; Almazov National Medical Research Centre</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>30</day><month>03</month><year>2022</year></pub-date><volume>2</volume><issue>2</issue><fpage>46</fpage><lpage>53</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ионин В.А., Павлова В.А., Баранова Е.И., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Ионин В.А., Павлова В.А., Баранова Е.И.</copyright-holder><copyright-holder xml:lang="en">Ionin V.A., Pavlova V.A., Baranova E.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://persmed.elpub.ru/jour/article/view/16">https://persmed.elpub.ru/jour/article/view/16</self-uri><abstract><p>   В обзоре обсуждаются актуальность проблемы синдрома обструктивного апноэ сна в реальной клинической практике, особенности диагностики и персонализированного подхода в терапии с учетом разных коморбидных состояний, рассматриваются результаты основных клинических исследований и рекомендации. Поиск литературы и отбор клинических исследований был проведен за период с 2000 по 2020 годы на сайтах Европейского и Российского обществ кардиологов, а также по базам данных PubMed, eLibrary, Google Scholar.</p></abstract><trans-abstract xml:lang="en"><p>   The review discusses the relevance of the problem of obstructive sleep apnea syndrome in real clinical practice, features of diagnostics and a personalized approach to therapy considering various comorbid conditions, a review of the results of major clinical studies and recommendations. Literature search and selection of clinical studies was carried out for the period from 2000 to 2020 on the websites of the European and Russian Societies of Cardiology, as well as databases PubMed, eLibrary, Google Scholar.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>апноэ</kwd><kwd>гипопноэ</kwd><kwd>персонализированная терапия</kwd><kwd>сердечно-сосудистые заболевания</kwd></kwd-group><kwd-group xml:lang="en"><kwd>apnea</kwd><kwd>cardiovascular diseases</kwd><kwd>hypopnea</kwd><kwd>personalized therapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ge L., Guyatt G., Tian J., Pan B., Chang Y., Chen Y., et al. Insomnia and risk of mortality from all-cause, cardiovascular disease, and cancer: Systematic review and meta-analysis of prospective cohort studies. 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