persmedРоссийский журнал персонализированной медициныRussian Journal for Personalized Medicine2782-38062782-3814ФОНД АЛМАЗОВА10.18705/2782-3806-2023-3-3-38-47persmed-161Research ArticleНЕЙРОХИРУРГИЯЭпилепсия у больных с глиомами: механизмы, лечение и влияние противосудорожной терапииEpilepsy in glioma patients: mechanisms, management, and impact of anticonvulsant therapyВасиленкоА. В.VasilenkoA. V.

Василенко Анна Владимировна, к.м.н., заведующий учебной частью, доцент кафедры нейрохирургии ИМО; доцент кафедры неврологии им. акад. С. Н. Давиденкова 

ул. Аккуратова, д. 2, Санкт-Петербург, 197341

Vasilenko Anna V., Head of teaching unit, Associate Professor of Neurosurgery Department; Associate Professor of Neurology Department named after acad. S. V. Davidenkov

Akkuratova str., 2, Saint Petersburg, 197341

vasilenko_anna@list.ruУлитинА. Ю.UlitinA. Yu.

Улитин Алексей Юрьевич, д.м.н. профессор, заслуженный врач РФ, заведующий кафедрой нейрохирургии ИМО; профессор кафедры нейрохирургии им. проф. А. Л. Поленова 

Санкт-Петербург

Ulitin Alexey Yu., Dr. of Sci. (Med.), Senior Research Fellow of Neurosurgery Department; Professor of Neurosurgery Departament named after prof. A. L. Polenov

Saint Petersburg

АблаевН. Р.AblaevN. R.

Аблаев Нариман Рустемович, ординатор 2 года обучения кафедры нейрохирургии ИМО

Санкт-Петербург

Ablaev Nariman R., resident of the 2nd year of training at the Department of Neurosurgery 

Saint Petersburg

ДиконенкоМ. В.DikonenkoM. V.

Диконенко Михаил Викторович, ординатор 2 года обучения кафедры нейрохирургии ИМО

Санкт-Петербург

Dikonenko Michail V., resident of the 2nd year of training at the Department of Neurosurgery 

Saint Petersburg

МансуровА. С.MansurovA. S.

Мансуров Ахмед Саипович, ординатор 2 года обучения кафедры нейрохирургии ИМО

Санкт-Петербург

Mansurov Ahmed S., resident of the 2nd year of training at the Department of Neurosurgery 

Saint Petersburg

ШайховМ. М.ShaihovM. M.

Шайхов Мадани Магомедович, ординатор 2 года обучения кафедры нейрохирургии ИМО

Санкт-Петербург

Shaihov Madani M., resident of the 2nd year of training at the Department of Neurosurgery 

Saint Petersburg

Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской Федерации; Федеральное государственное бюджетное образовательное учреждение высшего образования «Северо-Западный государственный медицинский университет имени И. И. Мечникова» Министерства здравоохранения Российской ФедерацииРоссияAlmazov National Medical Research Centre; Northern-Western State Medical University named after I. I. MechnikovRussian FederationФедеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской ФедерацииРоссияAlmazov National Medical Research CentreRussian Federation202327072023333847Copyright © Василенко А.В., Улитин А.Ю., Аблаев Н.Р., Диконенко М.В., Мансуров А.С., Шайхов М.М., 20232023Василенко А.В., Улитин А.Ю., Аблаев Н.Р., Диконенко М.В., Мансуров А.С., Шайхов М.М.Vasilenko A.V., Ulitin A.Y., Ablaev N.R., Dikonenko M.V., Mansurov A.S., Shaihov M.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://persmed.elpub.ru/jour/article/view/161

Эпилептические припадки являются общепризнанным симптомом первичных опухолей головного мозга, при их возникновении широко используются противосудорожные препараты. Данная статья посвящена опухоль-ассоциированной эпилепсии и применению противоэпилептических препаратов (ПЭП) у пациентов с глиомами. Рассмотрены общая частота и механизмы эпилептогенеза. Факторы, которые следует учитывать при использовании противоэпилептических препаратов, включая течение болезни и ее профилактику, наряду с ПЭП основной линии выбора (например, возможные побочные эффекты, фармакокинетика, явные побочные эффекты и влияние таких препаратов на общую выживаемость пациентов с опухоль-ассоциированной эпилепсией). Наконец, рассмотрены области будущих исследований патофизиологии и использования противосудорожных препаратов у пациентов с глиомами.

Seizures are a well-recognized symptom of primary brain tumors, and anticonvulsant use is common. This paper provides an overview of epilepsy and the use of anticonvulsants in glioma patients. Overall incidence and mechanisms of epileptogenesis are reviewed. Factors to consider with the use of antiepileptic drugs (AEDs) including incidence during the disease trajectory and prophylaxis along with considerations in the selection of anticonvulsant use (ie, potential side effects, drug interactions, adverse effects, and impact on survival) are also reviewed. Finally, areas for future research and exploring the pathophysiology and use of AEDs in this population are also discussed.

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The authors declare that there are no conflicts of interest present.