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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">persmed</journal-id><journal-title-group><journal-title xml:lang="ru">Российский журнал персонализированной медицины</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal for Personalized Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2782-3806</issn><issn pub-type="epub">2782-3814</issn><publisher><publisher-name>ФОНД АЛМАЗОВА</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18705/2782-3806-2022-2-3-71-77</article-id><article-id custom-type="elpub" pub-id-type="custom">persmed-20</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>СЕРДЕЧНО-СОСУДИСТЫЕ ЗАБОЛЕВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CARDIOVASCULAR DISEASES</subject></subj-group></article-categories><title-group><article-title>ПРИМЕНЕНИЕ ПУЛЬС-ДУПЛИКАТОРА В ЭКСПЕРИМЕНТАЛЬНЫХ ИССЛЕДОВАНИЯХ ПРОТЕЗОВ КЛАПАНОВ СЕРДЦА</article-title><trans-title-group xml:lang="en"><trans-title>POSSIBILITIES OF APPLICATION OF PULSE DUPLICATOR IN STUDYING THE AORTIC ROOT</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Квиндт</surname><given-names>П. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kvindt</surname><given-names>P. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Квиндт Павел Александрович, младший научный сотрудник НИЛ заболеваний с  избыточной кальцификацией</p><p>ул. Аккуратова, д. 2, Санкт-Петербург, 197341</p></bio><bio xml:lang="en"><p>Kvindt Pavel A., Junior Researcher of the Research Laboratory of diseases with excessive calcification</p><p>Akkuratova str., 2, Saint Petersburg, 197341</p></bio><email xlink:type="simple">kvindt_pa@almazovcentre.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Толпыгин</surname><given-names>Д. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Tolpygin</surname><given-names>D. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Толпыгин Дмитрий Сергеевич, к.м.н., врач сердечно-сосудистый хирург отделения сердечно-сосудистой хирургии № 3</p><p>ул. Аккуратова, д. 2, Санкт-Петербург, 197341</p></bio><bio xml:lang="en"><p>Tolpygin Dmitry S., Ph.D, Cardio-thoracic surgeon of the Department of cardio-thoracic surgery</p><p>Akkuratova str., 2, Saint Petersburg, 197341</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Успенский</surname><given-names>В. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Uspenskiy</surname><given-names>V. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Успенский Владимир Евгеньевич, д.м.н., заведующий НИЛ заболеваний аорты и аортального клапана</p><p>ул. Аккуратова, д. 2, Санкт-Петербург, 197341</p></bio><bio xml:lang="en"><p>Uspenskiy Vladimir E., MD, PhD, Head of the Research Laboratory of the aorta and aortic valve diseases</p><p>Akkuratova str., 2, Saint Petersburg, 197341</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Филиппов</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Filippov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Филиппов Алексей Александрович, младший научный сотрудник НИЛ заболеваний с  избыточной кальцификацией</p><p>ул. Аккуратова, д. 2, Санкт-Петербург, 197341</p></bio><bio xml:lang="en"><p>Filippov Aleksei A., Junior Researcher of the Research Laboratory of diseases with excessive calcification of the World-Class Research Centre for Personalized Medicine; Junior Researcher of the Research Laboratory of the aorta and aortic valve diseases, Cardio-thoracic surgeon of the Department of cardio-thoracic surgery</p><p>Akkuratova str., 2, Saint Petersburg, 197341</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской Федерации, Научный центр мирового уровня «Центр персонализированной медицины»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Almazov National Medical Research Centre, World-Class Research Centre for Personalized Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>30</day><month>03</month><year>2022</year></pub-date><volume>2</volume><issue>3</issue><fpage>71</fpage><lpage>77</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Квиндт П.А., Толпыгин Д.С., Успенский В.Е., Филиппов А.А., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Квиндт П.А., Толпыгин Д.С., Успенский В.Е., Филиппов А.А.</copyright-holder><copyright-holder xml:lang="en">Kvindt P.A., Tolpygin D.S., Uspenskiy V.E., Filippov A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://persmed.elpub.ru/jour/article/view/20">https://persmed.elpub.ru/jour/article/view/20</self-uri><abstract><p>Врожденные и приобретенные клапанные пороки сердца являются глобальной проблемой системы здравоохранения. Ежегодно проводится огромное количество операций протезирования клапанов сердца, но до сих пор не существует идеального искусственного заместителя сердечного клапана. Разработка новых протезов клапанов сердца непрерывно продолжается и включает оценку функционирования протезов клапанов и исследование их гидродинамических характеристик. Для подобных исследований были разработаны и применяются аппаратные системы дублирования импульсов (пульс-дупликаторы). В статье рассмотрены назначение и функции, механические компоненты, принцип работы устройства, программное обеспечение, возможности анализа, преимущества и недостатки подобных систем.</p></abstract><trans-abstract xml:lang="en"><p>Congenital and acquired valvular heart diseases are a global problem of the healthcare system. A huge number of prosthetic heart valve surgeries are performed annually, but there is still no ideal artificial substitute for a heart valve. The development of new prosthetic heart valves continues continuously, and includes an assessment of the functioning of prosthetic valves and the study of their hydrodynamic characteristics. Hardware pulse duplication systems (pulse duplicators) have been developed and used for such studies. The article discusses the purpose and functions, mechanical components, the principle of operation of the device, software, analysis capabilities, advantages and disadvantages of such systems.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>гемодинамический стенд</kwd><kwd>гидродинамика</kwd><kwd>клапаны сердца</kwd><kwd>программное обеспечение</kwd><kwd>протезы клапанов сердца</kwd><kwd>пульс-дупликатор</kwd></kwd-group><kwd-group xml:lang="en"><kwd>heart valves</kwd><kwd>heart valve prostheses</kwd><kwd>hemodynamic</kwd><kwd>hydrodynamics</kwd><kwd>pulse duplicator</kwd><kwd>software</kwd><kwd>test stand</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Sierad LN, Simionescu A, Albers C, Chen J, Maivelett J, Tedder ME, et al. Design and testing of a pulsatile conditioning system for dynamic endothelialization of polyphenol-stabilized tissue engineered heart valves. 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