persmedРоссийский журнал персонализированной медициныRussian Journal for Personalized Medicine2782-38062782-3814ФОНД АЛМАЗОВА10.18705/2782-3806-2024-4-4-340-347AYJMFMpersmed-279Research ArticleЛУЧЕВАЯ ДИАГНОСТИКАDIAGNOSTIC RADIOLOGYЭволюция метода МРТ и современные возможности использования в пренатальной диагностике аномалий развития плода (обзор литературы)Evolution of the MRT method and current possibilities of its use in prenatal diagnosis of foetal anomalies (literature review)АраслановаЛ. В.AraslanovaL. V.

Лариса Вакильевна Арасланова, к. м. н., заведующая отделением, доцент

Областной консультативно-диагностический центр; отделение лучевой диагностики; кафедра персонализированной и трансляционной медицины

Ростов-на-Дону

Larisa V. Araslanova, Candidate of medical sciences, Head of Department, Associate Professor

Regional Consultative and Diagnostic Centre; Radiation Diagnostics Department; Department of Personalised and Translational Medicine

Rostov-on-Don

СкосарьВ. Е.SkosarV. E.

Владимир Евгеньевич Скосарь, ординатор

344022; пер. Нахичеванский, 29; Ростов-на-Дону

Vladimir E. Skosar, resident

344022; Nakhichevansky Lane, 29; Rostov-on-Don

skosar.vova@yandex.ruДайсудоваА. Д.DaisudovaA. D.

Анастасия Дмитриевна Дайсудова, ассистент

кафедра персонализированной и трансляционной медицины

Ростов-на-Дону

Anastasia D. Daisudova, Assistant

Department of Personalised and Translational Medicine

Rostov-on-Don

РябченкоВ. А.RyabchenkoV. A.

Виктория Александровна Рябченко, к. м. н., ассистент

кафедра персонализированной и трансляционной медицины

Ростов-на-Дону

Victoria A., Ryabchenko, Candidate of Medical Sciences, Assistant

Department of Personalised and Translational Medicine

Rostov-on-Don

Федеральное государственное бюджетное образовательное учреждение высшего образования «Ростовский государственный медицинский университет» Министерства здравоохранения Российской Федерации; Государственное автономное учреждение Ростовской области «Областной консультативно-диагностический центр»РоссияRostov State Medical University; State Autonomous Institution of the Rostov Region “Regional Consultative and Diagnostic Centre”Russian FederationФедеральное государственное бюджетное образовательное учреждение высшего образования «Ростовский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияRostov State Medical UniversityRussian FederationФедеральное государственное бюджетное образовательное учреждение высшего образования «Ростовский государственный медицинский университет» Министерства здравоохранения Российской Федерации; Государственное автономное учреждение Ростовской области «Областной консультативно-диагностический центр»РоссияRostov State Medical UniversityRussian Federation20241309202444340347Copyright © Арасланова Л.В., Скосарь В.Е., Дайсудова А.Д., Рябченко В.А., 20242024Арасланова Л.В., Скосарь В.Е., Дайсудова А.Д., Рябченко В.А.Araslanova L.V., Skosar V.E., Daisudova A.D., Ryabchenko V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://persmed.elpub.ru/jour/article/view/279

   Статья представляет собой комплексный обзор эволюции методов магнитно­резонансной томографии (МРТ) для визуализации плода с начала XXI века по 2023 год. Основное вни­мание уделяется новым методам, протоколам и технологиям, включая применение МРТ на 1,5 Тл и 3 Тл. Рассматриваются тератогенные эффекты, сверхбыстрые последовательности, применение последовательностей Т1­ и Т2­взвешенных изображений, а также пе­редовые методы, такие как диффузно­взвешенная визуализация (DWI), технология SWI с управляемым волновым наложением в параллельной визуализации (CAIPI). Магнитно­резонансная томография плода становится ключевым методом в акушерской диагностике, существенно преодолевая ограничения ультразвукового исследования. Эволюция методов МРТ отражает постоянное стремление к повышению качества изо­бражений, снижению рисков и расширению диагностических возможностей.

   This article is a comprehensive review of the evolution of magnetic resonance imaging (MRI) techniques for fetal imaging from the beginning of the 21st century to 2023. The focus is on new techniques, protocols, and technologies, including the use of 1.5 Tesla and 3 Tesla MRI. Teratogenic effects, ultrafast sequences, application of T1­ and T2­weighted imaging sequenc­es, and advanced techniques such as diffusion­weighted imaging (DWI), SWI technology with guided wave overlay in parallel imaging (CAIPI) are reviewed. Fetal magnetic resonance imaging is becoming a key modality in obstetric diagnosis, signifi­cantly overcoming the limitations of ultrasound. The evolution of MRI techniques reflects a constant endeavour to improve image quality, reduce risks and expand diagnostic capabilities.

аномалии развитияМРТ плодапренатальная диагностика3 Тл МРТDWIIVIMdevelopmental anomaliesDWIfetal MRIIVIMprenatal diagnosis3 Tesla MRIReferencesGirard N, Raybaud Ch, Gambarelli D. MCU-PH Pediatric Neuroimaging: Fetal MR Imaging Recent Advances in Diagnostic. Neuroradiology. 2002;373–398. DOI: 10.1007/978-3-642-56662-2_23.Girard N, Raybaud Ch, Gambarelli D. MCU-PH Pediatric Neuroimaging: Fetal MR Imaging Recent Advances in Diagnostic. Neuroradiology. 2002;373–398. DOI: 10.1007/978-3-642-56662-2_23.Hubbard AM, Adzick NS, Crombleholme TM, et al. Left-sided congenital diaphragmatic hernia: value of prenatal MR imaging in preparation for fetal surgery. Radiology. 1997;203(3):636–640.Hubbard AM, Adzick NS, Crombleholme TM, et al. Left-sided congenital diaphragmatic hernia: value of prenatal MR imaging in preparation for fetal surgery. Radiology. 1997;203(3):636–640.Glastonbury CM, Kennedy AM. Ultrafast MRI of the fetus. Australasian Radiology. 2002;46:22–32.Glastonbury CM, Kennedy AM. Ultrafast MRI of the fetus. Australasian Radiology. 2002;46:22–32.Yamashita Y, Namimoto T, Abe Y, et al. Imaging of the fetus by a HASTE sequence. AJR Am J Roentgenol. 1997;168:513–519.Yamashita Y, Namimoto T, Abe Y, et al. Imaging of the fetus by a HASTE sequence. AJR Am J Roentgenol. 1997;168:513–519.Robinson AJ, Blaser S, Toi A, et al. The fetal cerebellar vermis: assessment for abnormal development by ultrasonography and magnetic resonance imaging. Ultrasound Q. 2007;23(3):211–23. DOI: 10.1097/RUQ.0b013e31814b162c.Robinson AJ, Blaser S, Toi A, et al. The fetal cerebellar vermis: assessment for abnormal development by ultrasonography and magnetic resonance imaging. Ultrasound Q. 2007;23(3):211–23. DOI: 10.1097/RUQ.0b013e31814b162c.Saleem SN. Fetal MRI: An approach to practice : A review. J Adv Res. 2014; 5(5):507–523.Saleem SN. Fetal MRI: An approach to practice : A review. J Adv Res. 2014; 5(5):507–523.Miller E, Ben-Sira L, Constantini S, et al. Impact of prenatal magnetic resonance imaging on postnatal neurosurgical treatment. J Neurosurg. 2006;105:203–9. DOI: 10.3171/ped.2006.105.3.203. PMID: 16970233.Miller E, Ben-Sira L, Constantini S, et al. Impact of prenatal magnetic resonance imaging on postnatal neurosurgical treatment. J Neurosurg. 2006;105:203–9. DOI: 10.3171/ped.2006.105.3.203. PMID: 16970233.Glenn OA, Barkovich AJ. Magnetic resonance imaging of the fetal brain and spine: an increasingly important tool in prenatal diagnosis, part 1. AJNR Am J Neuroradiol. 2006;27(8):1604–11.Glenn OA, Barkovich AJ. Magnetic resonance imaging of the fetal brain and spine: an increasingly important tool in prenatal diagnosis, part 1. AJNR Am J Neuroradiol. 2006;27(8):1604–11.Victoria T, Johnson AM, Edgar JC, et al. Comparison Between 1.5-T and 3-T MRI for Fetal Imaging: Is There an Advantage to Imaging With a Higher Field Strength? American Journal of Roentgenology. 2015;206:195–201. DOI: 10.2214/AJR.14.14205.Victoria T, Johnson AM, Edgar JC, et al. Comparison Between 1.5-T and 3-T MRI for Fetal Imaging: Is There an Advantage to Imaging With a Higher Field Strength? American Journal of Roentgenology. 2015;206:195–201. DOI: 10.2214/AJR.14.14205.Sapna R, Priscilla J, Abhimanyu K, et al. Fetal MRI: A pictorial essay. Indian J Radiol Imaging. 2016;26(01): 52–62.Sapna R, Priscilla J, Abhimanyu K, et al. Fetal MRI: A pictorial essay. Indian J Radiol Imaging. 2016;26(01): 52–62.Kazi AZ, Joshi PC, Kelkar AB, et al. MRI evaluation of pathologies affecting the corpus callosum: A pictorial essay. Indian J Radiol Imaging. 2013;23:321–32.Kazi AZ, Joshi PC, Kelkar AB, et al. MRI evaluation of pathologies affecting the corpus callosum: A pictorial essay. Indian J Radiol Imaging. 2013;23:321–32.Chartier AL, Bouvier MJ, McPherson DR, et al. The Safety of Maternal and Fetal MRI at 3 T. AJR Am J Roentgenol. 2019;213(5):1170–1173. DOI:10.2214/AJR.19.21400.Chartier AL, Bouvier MJ, McPherson DR, et al. The Safety of Maternal and Fetal MRI at 3 T. AJR Am J Roentgenol. 2019;213(5):1170–1173. DOI:10.2214/AJR.19.21400.Weisstanner C, Gruber GM, Brugger PC, et al. Fetal MRI at 3T-ready for routine use? British Journal of Radiology. 2017;90(1069):20160362. DOI: 10.1259/bjr.20160362.Weisstanner C, Gruber GM, Brugger PC, et al. Fetal MRI at 3T-ready for routine use? British Journal of Radiology. 2017;90(1069):20160362. DOI: 10.1259/bjr.20160362.Pugash D, Krssak M, Kulemann V, et al. Magnetic resonance spectroscopy of the fetal brain. Prenat Diagn. 2009;29:434–41. DOI: 10.1002/pd.2248.Pugash D, Krssak M, Kulemann V, et al. Magnetic resonance spectroscopy of the fetal brain. Prenat Diagn. 2009;29:434–41. DOI: 10.1002/pd.2248.Barrera CA, Francavilla ML, Serai SD, et al. Specific Absorption Rate and Specific Energy Dose: Comparison of 1.5-T versus 3.0-T Fetal MRI. Radiology. 2020;295(3):664–674. DOI: 10.1148/radiol.2020191550.Barrera CA, Francavilla ML, Serai SD, et al. Specific Absorption Rate and Specific Energy Dose: Comparison of 1.5-T versus 3.0-T Fetal MRI. Radiology. 2020;295(3):664–674. DOI: 10.1148/radiol.2020191550.Руденко Н.Н., Фокин А.В., Мащенко И.А. и др. Методические основы магнитно-резонансной томографии у беременных. Современные проблемы науки и образования. 2020;3. DOI:10.17513/spno.29911.Rudenko NN, Fokin AV, Mashchenko IA, et al. Methodological basis of magnetic resonance tomography in pregnant women. Modern problems of science and education. 2020;3. In Russian DOI:10.17513/spno.29911Manganaro L, Capuani S, Gennarini M, et al. Fetal MRI:’s new? A short review. Eur Radiol. 2023;7:41. DOI: 10.1186/s41747-023-00358-5.Manganaro L, Capuani S, Gennarini M, et al. Fetal MRI:’s new? A short review. Eur Radiol. 2023;7:41. DOI: 10.1186/s41747-023-00358-5.Powers AM, White C, Neuberger I, et al. Fetal MRI Neuroradiology: Indications. Clin Perinatol. 2022;49(3):573–586. DOI: 10.1016/j.clp.2022.05.001.Powers AM, White C, Neuberger I, et al. Fetal MRI Neuroradiology: Indications. Clin Perinatol. 2022;49(3):573–586. DOI: 10.1016/j.clp.2022.05.001.Dawood Y, Buijtendijk MFJ, Shah H, et al. Imaging fetal anatomy. Semin Cell Dev Biol. 2022;131:78–92. DOI: 10.1016/j.semcdb.2022.02.023.Dawood Y, Buijtendijk MFJ, Shah H, et al. Imaging fetal anatomy. Semin Cell Dev Biol. 2022;131:78–92. DOI: 10.1016/j.semcdb.2022.02.023.Capuani S, Guerreri M, Antonelli A, et al. Diffusion and perfusion quantified by Magnetic Resonance Imaging are markers of human placenta development in normal pregnancy. Placenta. 2017;58:33–39. DOI: 10.1016/j.placenta.2017.08.003.Capuani S, Guerreri M, Antonelli A, et al. Diffusion and perfusion quantified by Magnetic Resonance Imaging are markers of human placenta development in normal pregnancy. Placenta. 2017;58:33–39. DOI: 10.1016/j.placenta.2017.08.003.Colleran GC, Kyncl M, Garel C, et al. Fetal magnetic resonance imaging at 3 Tesla - the European experience. Pediatr Radiol. 2022;52(5):959–970. DOI: 10.1007/s00247-021-05267-6.Colleran GC, Kyncl M, Garel C, et al. Fetal magnetic resonance imaging at 3 Tesla - the European experience. Pediatr Radiol. 2022;52(5):959–970. DOI: 10.1007/s00247-021-05267-6.Akiyama S, Madan N, Graham G, et al. Regional brain development in fetuses with Dandy-Walker malformation: A volumetric fetal brain magnetic resonance imaging study. PLoS One. 2022;17(2):e0263535. DOI: 10.1371/journal.pone.0263535.Akiyama S, Madan N, Graham G, et al. Regional brain development in fetuses with Dandy-Walker malformation: A volumetric fetal brain magnetic resonance imaging study. PLoS One. 2022;17(2):e0263535. DOI: 10.1371/journal.pone.0263535.Кравченко Е.Н., Коломбет Е.В., Куклина Л.В. Современные аспекты прерывания беременности в поздние сроки. МиД. 2016; № 1.Kravchenko EN, Kolombet EV, Kuklina LV. Modern aspects of late termination of pregnancy. MiD. 2016;No 1. In RussianШаталов А.Е., Купина А.Д., Петров Ю.А. Стерильность женщин как следствие воспалительных заболеваний гениталий. Международный журнал прикладных и фундаментальных исследований. 2020;74–77.Shatalov AE, Kupina AD, Petrov YuA. Sterility of women as a consequence of inflammatory diseases of the genitals. International Journal of Applied and Fundamental Research. 2020;74–77. In RussianAnblagan D, Deshpande R, Jones NW, et al. The Effect of Maternal Diabetes on Placental Blood Flow Assessed Using IVIM. Abstract from The International Society for Magnetic Resonance in Medicine, Montreal, United Kingdom. 2011;19:151.Anblagan D, Deshpande R, Jones NW, et al. The Effect of Maternal Diabetes on Placental Blood Flow Assessed Using IVIM. Abstract from The International Society for Magnetic Resonance in Medicine, Montreal, United Kingdom. 2011;19:151.Liao Y, Sun T, Jiang L, et al. Detecting abnormal placental microvascular flow in maternal and fetal diseases based on flow-compensated and non-compensated intravoxel incoherent motion imaging. Placenta. 2022;119:17–23. DOI: 10.1016/j.placenta.2022.01.010.Liao Y, Sun T, Jiang L, et al. Detecting abnormal placental microvascular flow in maternal and fetal diseases based on flow-compensated and non-compensated intravoxel incoherent motion imaging. Placenta. 2022;119:17–23. DOI: 10.1016/j.placenta.2022.01.010.Masselli G, Cozzi D, Ceccanti S, et al. Fetal body MRI for fetal and perinatal management. Clin Radiol. 2021;76:708.e1–708.e8.Masselli G, Cozzi D, Ceccanti S, et al. Fetal body MRI for fetal and perinatal management. Clin Radiol. 2021;76:708.e1–708.e8.Linduska N, Dekan S, Messerschmidt A, et al. Placental pathologies in fetal MRI with pathohistological correlation. Placenta. 2009;6:555–9. DOI: 10.1016/j.placenta.2009.03.010.Linduska N, Dekan S, Messerschmidt A, et al. Placental pathologies in fetal MRI with pathohistological correlation. Placenta. 2009;6:555–9. DOI: 10.1016/j.placenta.2009.03.010.Sohlberg S, Mulic-Lutvica A, Lindgren P, et al. Placental perfusion in normal pregnancy and early and late preeclampsia: a magnetic resonance imaging study. Placenta. 2014;35(3):202–206. DOI: 10.1016/j.placenta.2014.01.008.Sohlberg S, Mulic-Lutvica A, Lindgren P, et al. Placental perfusion in normal pregnancy and early and late preeclampsia: a magnetic resonance imaging study. Placenta. 2014;35(3):202–206. DOI: 10.1016/j.placenta.2014.01.008.Петров Ю.А., Купина А.Д. Фетальное программирование — способ предупреждения заболеваний во взрослом возрасте. Медицинский Совет. 2020; 13: 50–56. DOI:10.21518/2079-701X-2020-13-50-56.Petrov YA, Kupina AD. Fetal programming is a way to prevent diseases in adulthood (literature review). Medical Council. 2020;13:50–56. In Russian DOI:10.21518/2079-701X-2020-13-50-56Петров Ю.А., Купина А.Д. Преэклампсия и эклампсия: перспективные возможности диагностики и профилактики. Мать и Дитя в Кузбассе. 2020; № 2(81):54–60.Petrov YA, Kupina AD. Preeclampsia and eclampsia: promising opportunities for diagnosis and prevention. Mother and Child in Kuzbass. 2020; No 2(81):54–60. In RussianKwon EJ, Kim YJ. What is fetal programming?: a lifetime health is under the control of in utero health. Obstet Gynecol Sci. 2017;60(6):506–519. DOI: 10.5468/ogs.2017.60.6.506.Kwon EJ, Kim YJ. What is fetal programming?: a lifetime health is under the control of in utero health. Obstet Gynecol Sci. 2017;60(6):506–519. DOI: 10.5468/ogs.2017.60.6.506.Wallingford MC, Benson C, Chavkin NW, et al. Placental Vascular Calcification and Cardiovascular Health: It Is Time to Determine How Much of Maternal and Offspring Health Is Written in Stone. Front Physiol. 2018;9:1044. DOI: 10.3389/fphys.2018.01044.Wallingford MC, Benson C, Chavkin NW, et al. Placental Vascular Calcification and Cardiovascular Health: It Is Time to Determine How Much of Maternal and Offspring Health Is Written in Stone. Front Physiol. 2018;9:1044. DOI: 10.3389/fphys.2018.01044.Fields JA, Garovic VD, Mielke MM, et al. Preeclampsia and cognitive impairment later in life. Am J Obstet Gynecol. 2017;217(1):74.e1–74.e11. DOI: 10.1016/j.ajog.2017.03.008.Fields JA, Garovic VD, Mielke MM, et al. Preeclampsia and cognitive impairment later in life. Am J Obstet Gynecol. 2017;217(1):74.e1–74.e11. DOI: 10.1016/j.ajog.2017.03.008.Mongraw-Chaffin ML, Cirillo PM, Cohn BA. Pre-eclampsia and cardiovascular disease death: prospective evidence from the child health and development studies cohort. Hypertension. 2010;56(1):166–71. DOI: 10.1161/HYPERTENSIONAHA.110.150078.Mongraw-Chaffin ML, Cirillo PM, Cohn BA. Pre-eclampsia and cardiovascular disease death: prospective evidence from the child health and development studies cohort. Hypertension. 2010;56(1):166–71. DOI: 10.1161/HYPERTENSIONAHA.110.150078.Pauli JM, Repke JT. Preeclampsia: Short-term and Long-term Implications. Obstet Gynecol Clin North Am. 2015;42(2):299–313. DOI: 10.1016/j.ogc.2015.01.007.Pauli JM, Repke JT. Preeclampsia: Short-term and Long-term Implications. Obstet Gynecol Clin North Am. 2015;42(2):299–313. DOI: 10.1016/j.ogc.2015.01.007.Deng J, Cao Y, Lu Y, et al. Value of placental virtual magnetic resonance elastography and intravoxel incoherent motion-based diffusion and perfusion in predicting adverse outcomes of small-for-gestationalage infants. Insights Imaging. 2023; 14: 153. DOI: 10.1186/s13244-023-01503-9.Deng J, Cao Y, Lu Y, et al. Value of placental virtual magnetic resonance elastography and intravoxel incoherent motion-based diffusion and perfusion in predicting adverse outcomes of small-for-gestationalage infants. Insights Imaging. 2023; 14: 153. DOI: 10.1186/s13244-023-01503-9.Le Bihan D. What can we see with IVIM MRI? Neuroimage. 2017;187:56–67. DOI: 10.1016/j.neuroimage.2017.12.062.Le Bihan D. What can we see with IVIM MRI? Neuroimage. 2017;187:56–67. DOI: 10.1016/j.neuroimage.2017.12.062.Yin Z, Magin RL, Klatt D. Simultaneous MR elastography and diffusion acquisitions: diffusion-MRE (dMRE). Magn Reson Med. 2014; 71: 1682–1688. DOI: 10.1002/mrm.25180.Yin Z, Magin RL, Klatt D. Simultaneous MR elastography and diffusion acquisitions: diffusion-MRE (dMRE). Magn Reson Med. 2014; 71: 1682–1688. DOI: 10.1002/mrm.25180.

The authors declare that there are no conflicts of interest present.