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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">persmed</journal-id><journal-title-group><journal-title xml:lang="ru">Российский журнал персонализированной медицины</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal for Personalized Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2782-3806</issn><issn pub-type="epub">2782-3814</issn><publisher><publisher-name>ФОНД АЛМАЗОВА</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">persmed-3</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КОЛОНКА ГЛАВНОГО РЕДАКТОРА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>EDITORS CORNER</subject></subj-group></article-categories><title-group><article-title>Персонализированная медицина. История, современное состояние проблемы и перспективы внедрения</article-title><trans-title-group xml:lang="en"><trans-title>Personalized Medicine. History, current state and future directions</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шляхто</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shlyakhto</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шляхто Евгений Владимирович, д.м.н., профессор, академик РАН, генеральный директор</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Shlyakhto Evgeny V., MD, PhD, Dr. Sc., Professor, Academician of the Russian Academy of Science, Director; Director</p><p>Saint Petersburg</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Конради</surname><given-names>А. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Konradi</surname><given-names>A. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Конради Александра Олеговна, д.м.н., профессор, чл.-корр. РАН, заместитель генерального директора, заведующий кафедрой организации управления и экономики здравоохранения Института медицинского образования Центра Алмазова</p><p>ул. Аккуратова, д. 2, Санкт-Петербург, Россия, 197341</p></bio><bio xml:lang="en"><p>Konradi Alexandra O., MD, Dr. Sc., Professor, Corresponding Member RAS, Deputy General Director for Research, Head of the Research Department of Arterial Hypertension, Head of the Department of Management Organization and Health Economics, Institute of Medical Education</p><p>Akkuratova str. 2, Saint Petersburg, Russia, 197341</p></bio><email xlink:type="simple">konradi_ao@almazovcentre.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской Федерации; Научный центр мирового уровня «Центр персонализированной медицины»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Almazov National Medical Research Centre; World-Class Research Centre for Personalized Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Almazov National Medical Research Centre</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>28</day><month>12</month><year>2021</year></pub-date><volume>1</volume><issue>1</issue><fpage>6</fpage><lpage>20</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шляхто Е.В., Конради А.О., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Шляхто Е.В., Конради А.О.</copyright-holder><copyright-holder xml:lang="en">Shlyakhto E.V., Konradi A.O.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://persmed.elpub.ru/jour/article/view/3">https://persmed.elpub.ru/jour/article/view/3</self-uri><abstract><p>В обзоре приводится история формирования направления персонализированной медицины, а также связанных с ней терминов и определений, оценка состояния проблемы на современном этапе и перспективы будущего. Приведен краткий анализ основных направлений персонализированной медицины и областей применения, преимущества подхода и барьеры на пути практического внедрения.</p></abstract><trans-abstract xml:lang="en"><p>The review assesses history of personalized approach in medicine, terminology and definitions and current situation in personalized medicine in the world. Major fields of implementation, classification, advantages and practical barriers are also discussed as well as future perspectives.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>персонализированная медицина</kwd><kwd>прецизионная медицина</kwd><kwd>фармакогенетика</kwd><kwd>омиксные технологии</kwd></kwd-group><kwd-group xml:lang="en"><kwd>personalized medicine</kwd><kwd>precision medicine</kwd><kwd>pragmacogenetics</kwd><kwd>OMICs-technologies</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Schwab K. 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