persmedРоссийский журнал персонализированной медициныRussian Journal for Personalized Medicine2782-38062782-3814ФОНД АЛМАЗОВА10.18705/2782-3806-2025-5-1-6-28TZSKZEpersmed-301Research ArticleВНУТРЕННИЕ БОЛЕЗНИINTERNAL MEDICINEБурая или бежевая жировая ткань – цель терапии, направленной на улучшение метаболического здоровья?Brown or beige adipose tissue – a target for metabolic health therapy?ТучинаТ. П.TuchinaT. P.

Тучина Таисия Павловна, врач-эндокринолог 

ул. Аккуратова, д. 2, Санкт-Петербург, 197341

Tuchina Taisiia P., endocrinologist 

Akkuratova str., 2, Saint Petersburg, 197341

КононоваЮ. А.KononovaYu. A.

Кононова Юлия Алексеевна, лаборант кафедры  эндокринологии

ул. Аккуратова, д. 2, Санкт-Петербург, 197341

Kononova Yulia A., laboratory assistant of the Department of Endocrinology 

Akkuratova str., 2, Saint Petersburg, 197341

ЗасыпкинГ. Г.ZasypkinG. G.

Засыпкин Герман Георгиевич, младший научный сотрудник НИЛ предиабета и метаболических нарушений НИО генетических рисков и персонифицированной профилактики НЦМУ «Центр персонализированной медицины»

ул. Аккуратова, д. 2, Санкт-Петербург, 197341

Zasypkin German G., Junior Researcher, Research Laboratory of Prediabetes and Metabolic Disorders, Research Institute of Genetic Risks and PersonalizedPrevention of World-Class Research Centre for Personalized Medicine

Akkuratova str., 2, Saint Petersburg, 197341

БабенкоА. Ю.BabenkoA. Yu.

Бабенко Алина Юрьевна, д.м.н., заведующий НИО генетических рисков и персонифицированной профилактики НЦМУ «Центр персонализированной медицины»

ул. Аккуратова, д. 2, Санкт-Петербург, 197341

Babenko Alina Yu., Doctor of Medical Sciences, Head of the Research Institute of Genetic Risks and Personalized Prevention of World-Class Research Centre for Personalized Medicine

Akkuratova str., 2, Saint Petersburg, 197341

alina_babenko@mail.ruФедеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской ФедерацииРоссияAlmazov National Medical Research CentreRussian Federation20250603202551628Copyright © Тучина Т.П., Кононова Ю.А., Засыпкин Г.Г., Бабенко А.Ю., 20252025Тучина Т.П., Кононова Ю.А., Засыпкин Г.Г., Бабенко А.Ю.Tuchina T.P., Kononova Y.A., Zasypkin G.G., Babenko A.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://persmed.elpub.ru/jour/article/view/301

Учитывая низкую эффективность лечения ожирения во всем мире, поиск новых путей решения этой проблемы остается высокоактуальным. Как перспективная мишень внимание исследователей привлекла бурая жировая ткань, которая, в отличие от белой, вовлечена в расход излишков энергии и поддержание метаболического здоровья. В организме человека присутствуют 2 ее подтипа – классическая бурая и бежевая. В настоящем обзоре предпринята попытка определить, есть ли различия в эффектах препаратов на эти подтипы бурой жировой ткани и в последствиях их активации.

The search for new ways to solve the problem of obesity is highly relevant, since the effectiveness of obesity treatment worldwide is low. A possible promising target for researchers is brown adipose tissue. Brown adipose tissue is involved in the expenditure of excess energy and the maintenance of metabolic health, unlike white adipose tissue. In the human body, there are 2 subtypes of brown adipose tissue – classic brown and beige. This review attempts to determine whether there are differences in the effects of drugs on these subtypes of brown adipose tissue and in the consequences of activating these subtypes.

 

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The authors declare that there are no conflicts of interest present.