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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">persmed</journal-id><journal-title-group><journal-title xml:lang="ru">Российский журнал персонализированной медицины</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal for Personalized Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2782-3806</issn><issn pub-type="epub">2782-3814</issn><publisher><publisher-name>ФОНД АЛМАЗОВА</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18705/2782-3806-2025-5-2-174-182</article-id><article-id custom-type="edn" pub-id-type="custom">CJCAWL</article-id><article-id custom-type="elpub" pub-id-type="custom">persmed-351</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ СЛУЧАИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL CASE</subject></subj-group></article-categories><title-group><article-title>Впервые диагностированные легочные артериовенозные мальформации у 16-летней пациентки с желудочковой экстрасистолией: клинический случай</article-title><trans-title-group xml:lang="en"><trans-title>Newly diagnosed pulmonary arteriovenous malformations in a 16-year-old female patient with ventricular extrasystole: a case report</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шеянова</surname><given-names>Е. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Sheyanova</surname><given-names>E. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шеянова Елизавета Сергеевна, врач — детский кардиолог консультативно-диагностического отделения</p><p>ул. Аккуратова, д. 2, Санкт-Петербург, 197341</p></bio><bio xml:lang="en"><p>Sheyanova Elizaveta S., pediatric cardiologist</p><p>Akkuratova str., 2, Saint Petersburg, 197341</p></bio><email xlink:type="simple">sheyanovaes@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Горбатых</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Gorbatykh</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Горбатых Артем Викторович, к.м.н., заведующий научно-исследовательской лабораторией интервенционной хирургии, эндоваскулярный хирург</p><p>ул. Аккуратова, д. 2, Санкт-Петербург, 197341</p></bio><bio xml:lang="en"><p>Gorbatykh Artem V., Cand. Med. Sci., Head of Research Laboratory of Interventional Surgery, Endovascular Surgeon</p><p>Akkuratova str., 2, Saint Petersburg, 197341</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мирончук</surname><given-names>Р. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Mironchuk</surname><given-names>R. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мирончук Ростислав Ростиславович, врач-рентгенолог, заведующий отделением лучевой диагностики № 3</p><p>ул. Аккуратова, д. 2, Санкт-Петербург, 197341</p></bio><bio xml:lang="en"><p>Mironchuk Rostislav R., radiologist, Head of the Department of Radiation Diagnostics No. 3</p><p>Akkuratova str., 2, Saint Petersburg, 197341</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чернова</surname><given-names>А. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Chernova</surname><given-names>A. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Чернова Анна Петровна, врач — детский кардиолог, врач ультразвуковой диагностики</p><p>ул. Аккуратова, д. 2, Санкт-Петербург, 197341</p></bio><bio xml:lang="en"><p>Chernova Anna P., pediatric cardiologist, ultrasonographer</p><p>Akkuratova str., 2, Saint Petersburg, 197341</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Никоненко</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikonenko</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Никоненко Анна Михайловна, заведующая консультативно-диагностическим отделением для детей, врач — детский хирург</p><p>ул. Аккуратова, д. 2, Санкт-Петербург, 197341</p></bio><bio xml:lang="en"><p>Nikonenko Anna M., pediatric surgeon, head of the children’s advisory department</p><p>Akkuratova str., 2, Saint Petersburg, 197341</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Копылов</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kopylov</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Копылов Владимир Владимирович, к.м.н., главный врач Клиники материнства и детства Университетской клиники; главный внештатный детский специалист анестезиолог-реаниматолог Комитета по здравоохранению Санкт-Петербурга</p><p>ул. Аккуратова, д. 2, Санкт-Петербург, 197341</p></bio><bio xml:lang="en"><p>Kopylov Vladimir V., PhD, Chief Physician of the Clinic of Maternity and Childhood of the University Clinic; Chief Pediatric Anesthesiology of the Health Committee of St. Petersburg</p><p>Akkuratova str., 2, Saint Petersburg, 197341</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Первунина</surname><given-names>Т. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Pervunina</surname><given-names>T. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Первунина Татьяна Михайловна, д.м.н., директор Института перинатологии и педиатрии, заведующая кафедрой перинатологии и педиатрии с клиникой</p><p>ул. Аккуратова, д. 2, Санкт-Петербург, 197341</p></bio><bio xml:lang="en"><p>Pervunina Tatyana M., MD, Director of the Institute of Perinatology and Pediatrics, Head of the Department of Perinatology and Pediatrics with a Clinic</p><p>Akkuratova str., 2, Saint Petersburg, 197341</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Васичкина</surname><given-names>Е. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Vasichkina</surname><given-names>E. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Васичкина Елена Сергеевна, д.м.н., главный научный сотрудник научно-исследовательского отдела сердечно-сосудистых заболеваний у детей</p><p>ул. Аккуратова, д. 2, Санкт-Петербург, 197341</p></bio><bio xml:lang="en"><p>Vasichkinа Elena S., MD, Chief Researcher of the Research Department of Cardiovascular Diseases in Children</p><p>Akkuratova str., 2, Saint Petersburg, 197341</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Almazov National Medical Research Centre</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>05</day><month>06</month><year>2025</year></pub-date><volume>5</volume><issue>2</issue><fpage>174</fpage><lpage>182</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шеянова Е.С., Горбатых А.В., Мирончук Р.Р., Чернова А.П., Никоненко А.М., Копылов В.В., Первунина Т.М., Васичкина Е.С., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Шеянова Е.С., Горбатых А.В., Мирончук Р.Р., Чернова А.П., Никоненко А.М., Копылов В.В., Первунина Т.М., Васичкина Е.С.</copyright-holder><copyright-holder xml:lang="en">Sheyanova E.S., Gorbatykh A.V., Mironchuk R.R., Chernova A.P., Nikonenko A.M., Kopylov V.V., Pervunina T.M., Vasichkina E.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://persmed.elpub.ru/jour/article/view/351">https://persmed.elpub.ru/jour/article/view/351</self-uri><abstract><p>Одна из причин хронической гипоксемии — это легочные артериовенозные мальформации, патофизиологической основой которых является шунтирование венозной крови в артериальный кровоток без этапа насыщения кислородом. Данная патология редко диагностируется в детском возрасте в связи с поздним дебютом клинических симптомов, а также отсутствием настороженности врачей педиатрического профиля в отношении этой редкой патологии. В настоящей статье представлен клинический случай пациентки 16 лет, подтверждающий важность тщательного физикального осмотра, сложность дифференциальной диагностики артериовенозных мальформаций и необходимость междисциплинарного подхода в лечении данной группы пациентов.</p></abstract><trans-abstract xml:lang="en"><p>One of the causes of chronic hypoxemia is pulmonary arteriovenous malformations, the pathophysiological basis of which is the shunting of venous blood into the arterial blood flow without the stage of oxygen saturation. This pathology is rarely diagnosed in childhood due to the late onset of clinical symptoms, as well as the lack of alertness of pediatricians in the field of this rare pathology. This article presents a clinical case of a 16-year-old patient, confirming the importance of a thorough physical examination, the complexity of differential diagnosis of arteriovenous malformations with other diseases and the need for an interdisciplinary approach to the treatment of this group of patients.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>артериовенозные мальформации</kwd><kwd>гипоксемия</kwd><kwd>десатурация</kwd><kwd>клинический случай</kwd><kwd>легочные артериовенозные мальформации</kwd><kwd>полицитемия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>arteriovenous malformations</kwd><kwd>clinical case</kwd><kwd>desaturation</kwd><kwd>hypoxemia</kwd><kwd>polycythemia</kwd><kwd>pulmonary arteriovenous malformations</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование выполнено в рамках государственного задания № 056-000081-25-00.</funding-statement><funding-statement xml:lang="en">The study was carried out within the framework of the state assignment No. 056-000081-25-00.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Shen Y, Su L, Wang D, et al. Overview of peripheral arteriovenous malformations: From diagnosis to treatment methods. J Interv Med. 2023;6(4):170–175.</mixed-citation><mixed-citation xml:lang="en">Shen Y, Su L, Wang D, et al. Overview of peripheral arteriovenous malformations: From diagnosis to treatment methods. J Interv Med. 2023;6(4):170–175.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Nakayama M, Nawa T, Chonan T, et al. Prevalence of pulmonary arteriovenous malformations as estimated by low-dose thoracic CT screening. Intern Med. 2012;51(13):1677–81.</mixed-citation><mixed-citation xml:lang="en">Nakayama M, Nawa T, Chonan T, et al. Prevalence of pulmonary arteriovenous malformations as estimated by low-dose thoracic CT screening. Intern Med. 2012;51(13):1677–81.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Albitar HAH, Segraves JM, Almodallal Y, et al. Pulmonary Arteriovenous Malformations in Nonhereditary Hemorrhagic Telangiectasia Patients: An 18-Year Retrospective Study. Lung. 2020;198(4):679–686.</mixed-citation><mixed-citation xml:lang="en">Albitar HAH, Segraves JM, Almodallal Y, et al. Pulmonary Arteriovenous Malformations in Nonhereditary Hemorrhagic Telangiectasia Patients: An 18-Year Retrospective Study. Lung. 2020;198(4):679–686.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Shin JH, Park SJ, Ko GY, et al. Embolotherapy for pulmonary arteriovenous malformations in patients without hereditary hemorrhagic telangiectasia. Korean J Radiol. 2010 May-Jun;11(3):312–9.</mixed-citation><mixed-citation xml:lang="en">Shin JH, Park SJ, Ko GY, et al. Embolotherapy for pulmonary arteriovenous malformations in patients without hereditary hemorrhagic telangiectasia. Korean J Radiol. 2010 May-Jun;11(3):312–9.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Pollak JS, Saluja S, Thabet A, et al. Clinical and anatomic outcomes after embolotherapy of pulmonary arteriovenous malformations. J Vasc Interv Radiol. 2006 Jan;17(1):35–44.</mixed-citation><mixed-citation xml:lang="en">Pollak JS, Saluja S, Thabet A, et al. Clinical and anatomic outcomes after embolotherapy of pulmonary arteriovenous malformations. J Vasc Interv Radiol. 2006 Jan;17(1):35–44.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Fuchizaki U, Miyamori H, Kitagawa S, et al. Hereditary haemorrhagic telangiectasia (Rendu-Osler-Weber disease). Lancet. 2003 Nov 1;362(9394):1490–4.</mixed-citation><mixed-citation xml:lang="en">Fuchizaki U, Miyamori H, Kitagawa S, et al. Hereditary haemorrhagic telangiectasia (Rendu-Osler-Weber disease). Lancet. 2003 Nov 1;362(9394):1490–4.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Успешное эндоваскулярное лечение легочной артериовенозной мальформации у ребенка / А. В. Горбатых, Д. А. Мананников, И. А. Сойнов и др. // Детские болезни сердца и сосудов. 2024. Т. 21, № 1. С. 66–73.</mixed-citation><mixed-citation xml:lang="en">Gorbatykh AV, Manannikov DA, Soynov IA, et al. Successful endovascular treatment of pulmonary arteriovenous malformation in a child. Detskiye bolezni serdtsa i sosudov=Children’s Heart and Vascular Diseases. 2024; 21(1):66–73. In Russian</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Swanson KL, Prakash UB, Stanson AW. Pulmonary arteriovenous fistulas: Mayo Clinic experience, 1982–1997. Mayo Clin Proc. 1999 Jul;74(7):671–80.</mixed-citation><mixed-citation xml:lang="en">Swanson KL, Prakash UB, Stanson AW. Pulmonary arteriovenous fistulas: Mayo Clinic experience, 1982–1997. Mayo Clin Proc. 1999 Jul;74(7):671–80.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Jaskolka J, Wu L, Chan RP, et al. Imaging of hereditary hemorrhagic telangiectasia. AJR Am J Roentgenol. 2004 Aug;183(2):307–14.</mixed-citation><mixed-citation xml:lang="en">Jaskolka J, Wu L, Chan RP, et al. Imaging of hereditary hemorrhagic telangiectasia. AJR Am J Roentgenol. 2004 Aug;183(2):307–14.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Chen CJ, Ding D, Derdeyn CP, et al. Brain arteriovenous malformations: A review of natural history, pathobiology, and interventions. Neurology. 2020 Nov 17;95(20):917–927.</mixed-citation><mixed-citation xml:lang="en">Chen CJ, Ding D, Derdeyn CP, et al. Brain arteriovenous malformations: A review of natural history, pathobiology, and interventions. Neurology. 2020 Nov 17;95(20):917–927.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Cura M, Elmerhi F, Suri R, et al. Vascular malformations and arteriovenous fistulas of the kidney. Acta Radiol. 2010 Mar;51(2):144–9.</mixed-citation><mixed-citation xml:lang="en">Cura M, Elmerhi F, Suri R, et al. Vascular malformations and arteriovenous fistulas of the kidney. Acta Radiol. 2010 Mar;51(2):144–9.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Buscarini E, Danesino C, Olivieri C, et al. Liver involvement in hereditary haemorrhagic telangiectasia or Rendu-Osler-Weber disease. Dig Liver Dis. 2005 Sep;37(9):635–45.</mixed-citation><mixed-citation xml:lang="en">Buscarini E, Danesino C, Olivieri C, et al. Liver involvement in hereditary haemorrhagic telangiectasia or Rendu-Osler-Weber disease. Dig Liver Dis. 2005 Sep;37(9):635–45.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Matsushige T, Kiya K, Satoh H, et al. Arteriovenous malformation of the scalp: case report and review of the literature. Surg Neurol. 2004 Sep;62(3):253–9.</mixed-citation><mixed-citation xml:lang="en">Matsushige T, Kiya K, Satoh H, et al. Arteriovenous malformation of the scalp: case report and review of the literature. Surg Neurol. 2004 Sep;62(3):253–9.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Plettendorff L, Werner JA, Wiegand S. Vascular Malformations of the Head and Neck in Children. In Vivo. 2023 Jan-Feb;37(1):366–370.</mixed-citation><mixed-citation xml:lang="en">Plettendorff L, Werner JA, Wiegand S. Vascular Malformations of the Head and Neck in Children. In Vivo. 2023 Jan-Feb;37(1):366–370.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Nguyen TH, Tran LT, Nguyen BC, et al. Rare Cause of Gastrointestinal Bleeding: A Case Report of Pancreatic Arteriovenous Malformation. Am J Case Rep. 2023 Nov 23;24:e941638.</mixed-citation><mixed-citation xml:lang="en">Nguyen TH, Tran LT, Nguyen BC, et al. Rare Cause of Gastrointestinal Bleeding: A Case Report of Pancreatic Arteriovenous Malformation. Am J Case Rep. 2023 Nov 23;24:e941638.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Pollak JS, Saluja S, Thabet A, et al. Clinical and anatomic outcomes after embolotherapy of pulmonary arteriovenous malformations. J Vasc Interv Radiol. 2006 Jan;17(1):35–44; quiz 45.</mixed-citation><mixed-citation xml:lang="en">Pollak JS, Saluja S, Thabet A, et al. Clinical and anatomic outcomes after embolotherapy of pulmonary arteriovenous malformations. J Vasc Interv Radiol. 2006 Jan;17(1):35–44; quiz 45.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Majumdar S, McWilliams JP. Approach to Pulmonary Arteriovenous Malformations: A Comprehensive Update. J Clin Med. 2020 Jun 19;9(6):1927.</mixed-citation><mixed-citation xml:lang="en">Majumdar S, McWilliams JP. Approach to Pulmonary Arteriovenous Malformations: A Comprehensive Update. J Clin Med. 2020 Jun 19;9(6):1927.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
