persmedРоссийский журнал персонализированной медициныRussian Journal for Personalized Medicine2782-38062782-3814ФОНД АЛМАЗОВАpersmed-8Research ArticleОБЗОРЫREVIEWERSТрансгенные модельные объекты нового поколения и их использование в персонализированной медицинеNew generation transgenic models in modern personalized medicineАндрееваД. Д.AndreevaD. D.

Андреева Дарья Дмитриевна, лаборант НИЛ нейрогенеза и нейродегенеративных заболеваний

Санкт-Петербург

Andreeva Daria D., Laboratory Assistant Neurogenesis and neurodegenerative diseases Research Laboratory

Saint Petersburg

СинегубовА. А.SinegubovA. A.

Синегубов Артем Александрович, внештатный сотрудник

Санкт-Петербург

Sinegubov Artem A., Freelance researcher

Saint Petersburg

БурзакН. А.BurzakN. A.

Бурзак Никита Александрович, младший научный сотрудник НИЛ нейрогенеза и нейродегенеративных заболеваний

Санкт-Петербург

Burzak Nikita A., Research Assistant Neurogenesis and neurodegenerative diseases Research Laboratory

Saint Petersburg

МурашоваЛ. А.MurashovaL. A.

Мурашова Лада Александровна, младший научный сотрудник НИЛ нейрогенеза и нейродегенеративных заболеваний

Санкт-Петербург

Murashova Lada A., Research Assistant Neurogenesis and neurodegenerative diseases Research Laboratory

Saint Petersburg

ВасютинаМ. Л.VasyutinaM. L.

Васютина Марина Львовна, Научный сотрудник НИЛ нейрогенеза и нейродегенеративных заболеваний

Санкт-Петербург

Vasyutina Marina L., Researcher Neurogenesis and neurodegenerative diseases Research Laboratory

Saint Petersburg

ДячукВ. А.DyachukV. A.

Дячук Вячеслав Алексеевич, к.б.н, ведущий научный сотрудник, заведующий НИЛ нейрогенеза и нейродегенеративных заболеваний

ул. Аккуратова, д. 2, Санкт-Петербург, Россия, 197341

Dyachuk Vyacheslav A., Head of Neurogenesis and neurodegenerative diseases Research Laboratory

Akkuratova str. 2, Saint Petersburg, Russia, 197341

slava_d83@mail.ruФедеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской Федерации; Научный центр мирового уровня «Центр персонализированной медицины»РоссияAlmazov National Medical Research Centre; World-Class Research Centre for Personalized MedicineRussian FederationФедеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской ФедерацииРоссияAlmazov National Medical Research CentreRussian Federation2021281220211195117Copyright © Андреева Д.Д., Синегубов А.А., Бурзак Н.А., Мурашова Л.А., Васютина М.Л., Дячук В.А., 20212021Андреева Д.Д., Синегубов А.А., Бурзак Н.А., Мурашова Л.А., Васютина М.Л., Дячук В.А.Andreeva D.D., Sinegubov A.A., Burzak N.A., Murashova L.A., Vasyutina M.L., Dyachuk V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://persmed.elpub.ru/jour/article/view/8

В обзоре рассмотрены основные направления работы с модельными организмами (Danio rerio, Mus musculus) в области современной персонализированной медицины, представлены основные подходы к трансгенезу, позволяющие более точно моделировать конкретные патологии человека. Описаны существующие модельные системы для изучения атеросклероза, дислипидемических растройств, нейродегенеративных заболеваний. Упомянуты трехмерные клеточные технологии, применимые в рамках персонализированного подхода к пациенту.

The review considers the main trends of investigation in model organisms (Danio Rerio, Mus musculus) in modern personalized medicine, presents the main approaches to transgenesis, allowing more accurate modeling of specific human pathologies. Existing model systems for studying atherosclerosis, dyslipidemic disorders, neurodegenerative diseases are described. Three-dimensional cellular technologies applicable within a personalized approach to a patient are mentioned.

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The authors declare that there are no conflicts of interest present.