100 years of vitamin D. The impact of vitamin D level in the time of COVID-19 pandemic
https://doi.org/10.18705/2782-3806-2022-2-6-33-41
Abstract
The year 2022 marks the 100th anniversary of the vitamin D discovery, however, vitamin D insufficiency and deficiency is globally widespread both in Russia and around the world. At the same time, the COVID-19 pandemic poses a serious challenge to global health. To date, more and more evidence is emerging to consider vitamin D deficiency as a modifiable COVID-19 severe course risk factor. Current review presents possible mechanisms behind the immunomodulatory effects of vitamin D, as well as shows the relationship between the vitamin D level and the course of COVID-19. In addition, the therapeutic potential of cholecalciferol supplementation to standard therapy for COVID-19 is being discussed.
About the Authors
K. A. Golovatyuk
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Golovatyuk Ksenia A., MD, laboratory research assistant of Clinical Endocrinology Laboratory of the Institute of Endocrinology
Akkuratova str., 2, Saint Petersburg, 197341
A. A. Mikhailova
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Mikhailova Arina A., laboratory research assistant of New Coronavirus Infection and Postcovid Syndrome Laboratory of World-Class Research Centre for Personalized Medicine, resident of the Department of Endocrinology, specialty “Endocrinology”
Saint Petersburg
D. I. Lagutina
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Lagutina Daria I., laboratory research assistant of New Coronavirus Infection and Postcovid Syndrome Laboratory of World-Class Research Centre for Personalized Medicine, resident of the Department of Endocrinology, specialty “Endocrinology”
Saint Petersburg
A. T. Chernikova
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Chernikova Alena T., MD, junior researcher of Clinical Endocrinology Laboratory of the Institute of Endocrinology
Saint Petersburg
T. L. Karonova
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Karonova Tatiana L., MD, D. Sc. (Med.), head of New Coronavirus Infection and Postcovid Syndrome Laboratory of World-Class Research Centre for Personalized Medicine, chief researcher of Clinical Endocrinology Laboratory, professor of the Department of internal medicine
Saint Petersburg
References
1. Jones G. 100 YEARS OF VITAMIN D: Historical aspects of vitamin D. Endocr Connect. 2022;11(4):e210594. DOI:10.1530/EC-21-0594.
2. Suplotova LA, Avdeeva VA, Pigarova EA, et al. The first Russian multicenter non-interventional registry study to study the incidence of vitamin D deficiency and insufficiency in Russian Federation. Terapevticheskii archiv. 2021;93(10):1209–1216. In Russian [Суплотова Л.А., Авдеева В.А., Пигарова Е.А., Трошина Е.А. и др. Первое российское многоцентровое неинтервенционное регистровое исследование по изучению частоты дефицита и недостаточности витамина D в Российской Федерации у взрослых. Терапевтический архив. 2021; 93 (10): 1209–1216.] DOI: 10.26442/00403660.2021.10.201071.
3. Cashman KD. Global differences in vitamin D status and dietary intake: a review of the data. Endocr Connect. 2022;11(1):e210282. DOI:10.1530/EC-21-0282.
4. Carpagnano GE, Di Lecce V, Quaranta VN, et al. Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19. J Endocrinol Invest. 2021;44(4):765–771. DOI:10.1007/s40618-020-01370-x.
5. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline [published correction appears in J Clin Endocrinol Metab. 2011 Dec;96(12):3908. J Clin Endocrinol Metab. 2011;96(7):1911–1930. DOI:10.1210/jc.2011-0385.
6. Pike JW, Meyer MB, Lee SM, et al. The vitamin D receptor: contemporary genomic approaches reveal new basic and translational insights. J Clin Invest. 2017;127(4):1146–1154. DOI:10.1172/JCI88887.
7. Bouillon R, Marcocci C, Carmeliet G, et al. Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions. Endocr Rev. 2019;40(4):1109–1151. DOI:10.1210/er.2018-00126.
8. Hewison M, Freeman L, Hughes SV, et al. Differential regulation of vitamin D receptor and its ligand in human monocyte-derived dendritic cells. J Immunol. 2003;170(11):5382–5390. DOI:10.4049/jimmunol.170.11.5382.
9. Ginde AA, Mansbach JM, Camargo CA Jr. Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2009;169(4):384–390. DOI:10.1001/archinternmed.2008.560.
10. Pham H, Rahman A, Majidi A, Waterhouse M, Neale RE. Acute Respiratory Tract Infection and 25-Hydroxyvitamin D Concentration: A Systematic Review and Meta-Analysis. Int J Environ Res Public Health. 2019;16(17):3020. Published 2019 Aug 21. DOI:10.3390/ijerph16173020.
11. Liu PT, Stenger S, Li H, et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science. 2006;311(5768):1770–1773. DOI:10.1126/science.1123933.
12. Adams JS, Ren S, Liu PT, et al. Vitamin d-directed rheostatic regulation of monocyte antibacterial responses. J Immunol. 2009;182(7):4289–4295. DOI:10.4049/jimmunol.0803736.
13. Agier J, Efenberger M, Brzezińska-Błaszczyk E. Cathelicidin impact on inflammatory cells. Cent Eur J Immunol. 2015;40(2):225–235. DOI:10.5114/ceji.2015.51359.
14. Barlow PG, Svoboda P, Mackellar A, et al. Antiviral activity and increased host defense against influenza infection elicited by the human cathelicidin LL37. PLoS One. 2011;6(10):e25333. DOI:10.1371/journal.pone.0025333.
15. Cantorna MT, Snyder L, Lin YD, Yang L. Vitamin D and 1,25(OH)2D regulation of T cells. Nutrients. 2015;7(4):3011–3021. Published 2015 Apr 22. DOI:10.3390/nu7043011.
16. Preventive effects of vitamin D on seasonal influenza a in infants: a multicenter, randomized, open, controlled clinical trial / J. Zhou, et al. // Pediatr Infect Dis J. — 2018. — Vol. 37, № 8. — Р. 749–754. https://doi.org/10.1097/INF.0000000000001890
17. Effects of vitamin D supplements on influenza A illness during the 2009 H1N1 pandemic: A randomized controlled trial / M. Urashima, H. Mezawa, M. Noya, C. A. Camargo Jr // Food Funct. — 2014. — Vol. 5, № 9. Р. 2365–2370. https://doi.org/10.1039/c4fo00371c.52
18. High-dose monthly vitamin D for prevention of acute respiratory infection in older longterm care residents: a randomized clinical trial / A.A. Ginde, et al. // J Am Geriatrics Society. — 2017. — Vol. 65, № 3. — Р. 496–503. https://doi.org/10.1111/jgs.14679
19. Berry D, Hesketh K, Power C, Hyppönen E. (2011). Vitamin D status has a linear association with seasonal infections and lung function in British adults. British Journal of Nutrition, 106(9), 1433–1440. DOI:10.1017/S0007114511001991.
20. Urashima M, Segawa T, Okazaki M, et al. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr. 2010 May;91(5):1255–60. DOI: 10.3945/ajcn.2009.29094. Epub 2010 Mar 10. PMID: 20219962.
21. Ginde AA, Blatchford P, Breese K, et al. High-Dose Monthly Vitamin D for Prevention of Acute Respiratory Infection in Older Long-Term Care Residents: A Randomized Clinical Trial. J. Am. Geriatr. Soc. 2017;65:496–503. DOI: 10.1111/jgs.14679. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
22. Murdoch DR, Slow S, Chambers ST et al. Effect of vitamin D3 supplementation on upper respiratory tract infections in healthy adults: the VIDARIS randomized controlled trial. JAMA. 2012 Oct 3;308(13):1333–9. DOI: 10.1001/jama.2012.12505. PMID: 23032549.
23. Putative roles of vitamin D in modulating immune response and immunopathology associated with COVID-19 / R. Kumar, et al. // Virus Res. — 2021. — Vol. 292. — P. 198235. https://doi.org/10.1016/j.virusres.2020.198235
24. Pre-infection 25-hydroxyvitamin D3 levels and association with severity of COVID-19 illness / A. A. Dror, et al. // PloS one. — 2022. — Vol. 17, № 2. — Р. e0263069. https://doi.org/10.1371/journal.pone.026306,
25. Bikle DD. Vitamin D regulation of immune function during COVID-19 / D.D. Bikle // Rev Endocr Metab Disord. — 2022. — Vol. 23, № 2. P. 279–285. https://doi.org/10.1007/s11154-021-09707-4
26. Infante M, Buoso A, Pieri M et al. (2022). Low Vitamin D Status at Admission as a Risk Factor for Poor Survival in Hospitalized Patients With COVID-19: An Italian Retrospective Study, Journal of the American Nutrition Association, 41:3, 250–265. DOI: 10.1080/07315724.2021.1877580.
27. Kaya MO, Pamukçu E, Yakar B. The role of vitamin D deficiency on COVID-19: a systematic review and metaanalysis of observational studies. Epidemiol Health. 2021;43:e2021074. DOI: 10.4178/epih.e2021074. Epub 2021 Sep 23. PMID: 34607398; PMCID: PMC8769802.
28. Chiodini I, Gatti D, Soranna D, et al. Vitamin D Status and SARS-CoV-2 Infection and COVID-19 Clinical Outcomes. Front Public Health. 2021 Dec 22;9:736665. DOI: 10.3389/fpubh.2021.736665. PMID: 35004568; PMCID: PMC8727532.
29. Kaufman HW, Niles JK, Kroll MH, et al. SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels. PLoS ONE. 2020:15(9):e0239252. DOI: https://doi.org/10.1371/journal.pone.0239252.
30. D’Avolio A, Avataneo V, Manca A, et al. 25-Hydroxyvitamin D Concentrations Are Lower in Patients with Positive PCR for SARS-CoV-2. Nutrients. 2020 May 9;12(5):1359. DOI: 10.3390/nu12051359. PMID: 32397511; PMCID: PMC7285131^74.
31. Meltzer DO, Best TJ, Zhang H, et al. Association of Vitamin D Status and Other Clinical Characteristics With COVID-19 Test Results. JAMA Netw Open. 2020 Sep 1;3(9):e2019722. DOI: 10.1001/jamanetworkopen.2020.19722. PMID: 32880651; PMCID: PMC7489852.
32. Hastie CE, Mackay DF, Ho F, et al. Vitamin D concentrations and COVID-19 infection in UK Biobank. Diabetes Metab Syndr. 2020 Jul-Aug;14(4):561–565. DOI: 10.1016/j.dsx.2020.04.050. Epub 2020 May 7. Erratum in: Diabetes Metab Syndr. 2020 Sep — Oct;14(5):1315–1316. PMID: 32413819; PMCID: PMC7204679.
33. Radujkovic A, Hippchen T, Tiwari-Heckler S, Dreher S, Boxberger M, Merle U. Vitamin D Deficiency and Outcome of COVID-19 Patients. Nutrients. 2020 Sep 10;12(9):2757. DOI: 10.3390/nu12092757. PMID: 32927735; PMCID: PMC7551780.
34. AlSafar H, Grant WB, Hijazi R, et al. COVID-19 Disease Severity and Death in Relation to Vitamin D Status among SARS-CoV-2-Positive UAE Residents. Nutrients. 2021 May 19;13(5):1714. DOI: 10.3390/nu13051714. PMID: 34069412; PMCID: PMC8159141.
35. Pereira M, Damascena A D, Galvão Azevedo L M, et al. (2022). Vitamin D deficiency aggravates COVID-19: systematic review and meta-analysis, Critical Reviews in Food Science and Nutrition, 62:5, 1308–1316, DOI: 10.1080/10408398.2020.1841090.
36. D’Ecclesiis O, Gavioli C, Martinoli C, et al. Vitamin D and SARS-CoV2 infection, severity and mortality: A systematic review and meta-analysis. PLoS One. 2022;17(7):e0268396. Published 2022 Jul 6. DOI:10.1371/journal.pone.0268396.
37. Pizzini A, Aichner M, Sahanic S, et al. Impact of Vitamin D Deficiency on COVID-19-A Prospective Analysis from the CovILD Registry. Nutrients. 2020;12(9):2775. Published 2020 Sep 11. DOI:10.3390/nu12092775.
38. Karonova TL, Kudryavtsev IV, Golovatyuk KA, et al. Vitamin D Status and Immune Response in Hospitalized Patients with Moderate and Severe COVID-19. Pharmaceuticals (Basel). 2022;15(3):305. Published 2022 Mar 2. DOI:10.3390/ph15030305.
39. Murai IH, Fernandes AL, Sales LP, et al. Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial. JAMA. 2021;325(11):1053– 1060. DOI:10.1001/jama.2020.26848.
40. Karonova TL, Golovatyuk KA, Kudryavtsev IV, et al. Effect of Cholecalciferol Supplementation on the Clinical Features and Inflammatory Markers in Hospitalized COVID-19 Patients: A Randomized, OpenLabel, Single-Center Study. Nutrients. 2022;14(13):2602. Published 2022 Jun 23. DOI:10.3390/nu14132602.
41. Entrenas Castillo M, Entrenas Costa LM, Vaquero Barrios JM, et al. “Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study”. J Steroid Biochem Mol Biol. 2020;203:105751. DOI:10.1016/j.jsbmb.2020.105751.
42. Alcala-Diaz JF, Limia-Perez L, Gomez-Huelgas R, et al. Calcifediol Treatment and Hospital Mortality Due to COVID-19: A Cohort Study. Nutrients. 2021;13(6):1760.
43. Published 2021 May 21. DOI:10.3390/nu1306176.
44. Клинические рекомендации: дефицит витамина D у взрослых: диагностика, лечение и профилактика / Е. А. Пигарова и др. — Москва, 2015.
Review
For citations:
Golovatyuk K.A., Mikhailova A.A., Lagutina D.I., Chernikova A.T., Karonova T.L. 100 years of vitamin D. The impact of vitamin D level in the time of COVID-19 pandemic. Russian Journal for Personalized Medicine. 2022;2(6):33-41. (In Russ.) https://doi.org/10.18705/2782-3806-2022-2-6-33-41
Views:
374
Email this article 