Amyloidosis of the gastrointestinal tract. Clinical cases
E. G. Solonitsyn,
Iu. Sh. Alieva,
S. Sh. Seyfedinova,
D. G. Baranov,
L. B. Mitrofanova,
R. V. Grozov,
A. A. Perminova
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Abstract
Amyloidosis is a group of diseases characterized by extracellular deposition of fibrillar protein (amyloid) in tissues and organs, consisting of β-sheet plates. The clinical manifestations and the endoscopic picture of amyloidosis are diverse and not very specific, which makes it difficult for specialists to make a diagnosis. The most common manifestations from the gastrointestinal tract are observed in AL-amyloidosis. The morphological diagnosis is made by detecting the characteristic apple-green birefringence in polarized light after staining with Congo red. This article presents clinical cases of diagnosis of amyloidosis of the gastrointestinal tract and modern literature data.
About the Authors
E. G. Solonitsyn
Almazov National Medical Research Centre; World-Class Research Centre for Personalized Medicine
Russian Federation
Russian Federation
Solonitsyn Evgeny G., PhD., Head of the Endoscopy Department, Associate Professor of the Department of Surgical Diseases with the Clinic; Head of the Research Laboratory of Oncological Diseases of the Digestive System
Saint Petersburg
Iu. Sh. Alieva
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Alieva Iuliia Sh., Endoscopist
Akkuratova str. 2, Saint Petersburg, Russia, 197341
S. Sh. Seyfedinova
World-Class Research Centre for Personalized Medicine
Russian Federation
Russian Federation
Seyfedinova Sabina Sh., Junior Researcher, Research Laboratory of Oncological Diseases of the Digestive System
Saint Petersburg
D. G. Baranov
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Baranov Dmitry G., Endoscopist, Gastroenterologist
Saint Petersburg
L. B. Mitrofanova
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Mitrofanova Lyubov B., MD, Dr. Sc., Pathomorphologist, Associate Professor, Head of the Research Laboratory of Pathomorphology, Chief Researcher of the Research Laboratory of Pathomorphology
Saint Petersburg
R. V. Grozov
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Grozov Roman V., PhD., Pathomorphologist
Saint Petersburg
A. A. Perminova
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Perminova Anastasia A., Pathomorphologist
Saint Petersburg
References
1. Khan MF, Falk RH. Amyloidosis. Postgrad Med J. 2001;77(913):686-693. https://doi.org/10.1136/pmj.77.913.686.
2. Merlini G, Bellotti V. Molecular mechanisms of amyloidosis. N Engl J Med. 2003;349(6):583-596. https://doi.org/10.1056/ NEJMra023144.
3. Bansal R, Syed U, Walfish J, et al. A. Small bowel amyloidosis. Curr Gastroenterol Rep. 2018;20(3):11. https://doi.org/10.1007/s11894-018-0616-y.
4. Benson MD, Buxbaum JN, Eisenberg DS, et al. Amyloid nomenclature 2018: recommendations by the International Society of Amyloidosis (ISA) nomenclature committee. Amyloid. 2019;25(4):215-219. https://doi.org/10.1080/13506129.2018.1549825.
5. Ebert EC, Nagar M. Gastrointestinal manifestations of amyloidosis. Am J Gastroenterol. 2008;103(3):776-787. https://doi.org/10.1111/j.1572-0241.2007.01669.x.
6. Shah KB, Inoue Y, Mehra MR. Amyloidosis and the heart: a comprehensive review. Arch Intern Med. 2006;166(17):1805-1813. https://doi.org/10.1001/archinte.166.17.1805.
7. Sekijima Y. J Neurol Neurosurg Psychiatry Published Online First: [please include Day Month Year]. https://doi.org/10.1136/jnnp2014-308724.
8. Carlson HC, Breen JF. Amyloidosis and plasma cell dyscrasias: gastrointestinal involvement. Semin Roentgenol. 1986;21(2):128-138. https://doi.org/10.1016/0037-198x(86)90029-5.
9. Heitzman EJ, Heitzman GC, Elliott CF. Primary esophageal amyloidosis. Report of a case with bleeding, perforation, and survival following resection. Arch Intern Med. 1962;109:595-600. https://doi.org/10.1001/archinte.1962.03620170093015
10. Rubinow A, Burakoff R, Cohen AS, et al. Esophageal manometry in systemic amyloidosis. A study of 30 patients. Am J Med. 1983;75(6): 951-956. https://doi.org/10.1016/0002-9343(83)90874-4.
11. Suris X, Moya F, Panes J, et al. Achalasia of the esophagus in secondary amyloidosis. Am J Gastroenterol. 1993;88(11):1959-1960.
12. Iijima-Dohi N, Shinji A, Shimizu T, et al. Recurrent gastric hemorrhaging with large submucosal hematomas in a patient with primary al systemic amyloidosis: endoscopic and histopathological findings. Intern Med. 2004;43(6):468-472. https://doi.org/10.2169/internalmedicine.43.468.
13. Brown SJ, Shackleton M, Salem H, et al. Gastrocolic fistula complicating primary (AL) Amyloidosis. J Gastroenterol Hepatol. 2002;17(1):110-111. https://doi.org/10.1046/j.1440-1746.2002.02655.x.
14. Gilat T, Spiro HM. Amyloidosis and the gut. Am J Dig Dis. 1968;13(7):619-633. https://doi.org/10.1007/bf02232969. 15. Vernon SE. Amyloid colitis. Dis Colon Rectum. 1982;25(7):728-730. https://doi.org/10.1007/bf02629550.
15. Chen J-H, Lai S-J, Tsai P-P, et al. Localized amyloidosis mimicking carcinoma of the colon. AJR Am J Roentgenol. 2002;179:536-537. https://doi.org/10.2214/ajr.179.2.1790536.
16. Rives S, Pera M, Rosiñol L, et al. Primary systemic amyloidosis presenting as a colonic stricture: successful treatment with left hemicolectomy followed by autologous hematopoietic stem-cell transplantation. Dis Colon Rectum. 2002;45(9):1263-1266. https://doi.org/10.1007/s10350-004-6403-x.
17. Biggers JA, Remmers AR, Lindley JD, et al. Femoral neuropathy and ischemic colitis associated with amyloidosis in hemodialysis patients. Ann Surg.1975;182(2):161-162. https://doi.org/10.1097/00000658-197508000-00014.
18. García-González R, Fernández FA, Garijo FM, et al. Amyloidosis of the rectum mimicking collagenous colitis. Pathol Res Pract. 1998;194(10):731-735. https://doi.org/10.1016/s0344-0338(98)80134-9.
19. Tada S, Iida M, Yao T, et al. Endoscopic features in amyloidosis of the small intestine: clinical and morphologic differences between chemical types of amyloid protein. Gastrointest Endosc. 1994;40(1):45-50. https://doi.org/10.1016/S0016-5107(94)70008-7.
20. Iida T, Yamano H, Nakase H. Systemic amyloidosis with gastrointestinal involvement: Diagnosis from endoscopic and histological views. J Gastroenterol Hepatol. 2018;33(3):583-590. https://doi.org/10.1111/jgh.13996
21. Tada S, Iida M, Iwashita A, et al. Endoscopic and biopsy findings of the upper digestive tract in patients with amyloidosis. Gastrointest Endosc. 1990;36:10-14.
22. Freudenthaler S, Hegenbart U, Schönland S, et al. Amyloid in biopsies of the gastrointestinal tract - a retrospective observational study on 542 patients. Virchows Arch. 2016;468:569-577. Cowan AJ, Skinner M, Seldin DC, et al. Amyloidosis of the gastrointestinal tract: a 13-year, single-center, referral experience. Haematologica. 2013;98:141-146.
23. Ikegaya N, Kobayashi S, Hishida A, et al. Colonic dilatation due to dialysis - related amyloidosis. Am J Kidney Dis. 1995;25(5):807-809. https://doi.org/10.1016/0272-6386(95)90559-6.
24. Sanath Kumar S, Appavu SS, Abcarian H, et al. Amyloidosis of the colon. Dis Colon Rectum. 1983;26(8): 541-544. https://doi.org/10.1007/bf02563751.
25. Legge DA, Wollaeger EE, Carlson HC. Intestinal pseudo-obstruction in systemic amyloidosis. Gut. 1970;11(9):764-767. https://doi.org/10.1136/gut.11.9.764.
26. Fraser AG, Arthur JF, Hamilton I. Intestinal pseudoobstruction secondary to amyloidosis responsive to cisapride. Digestive Diseases and Sciences. 1991;36(4):532-535. https://doi.org/10.1007/bf01298889.
27. Hiramatsu K, Kaneko S, Shirota Y, et al. Digestive Diseases and Sciences. 1998;43(8):1824-1830. https://doi.org/10.1023/a:1018856324810.
28. Maeshima E, Yamada Y, Yukawa S. Massive gastrointestinal hemorrhage in a case of amyloidosis secondary to rheumatoid arthritis: case report. Scand J Rheumatol. 1999;28(4):262-264. https://doi.org/10.1080/03009749950155670
29. Sánchez JAG, Molinero RM, Sayans JD, et al. Colonic perforation by amyloidosis. Dis Colon Rectum. 1989;32(5):437-440. https://doi.org/10.1007/bf02563700.
30. Alcalde-Vargas A, Leo-Carnerero E, Rojas- Mercedes N, et al. Correlation between location of amyloid deposits and endoscopic and clinical manifestations in symptomatic gastrointestinal amyloidosis. Rev Esp Enferm Dig. 2015;107(1):49-51.
31. Bansal R, Syed U, Walfish J, et al. Small Bowel Amyloidosis. Curr Gastroenterol Rep. 2018;20(3):11. https://doi.org/10.1007/s11894-018-0616-y.
32. Hui YT, Lam TW, Yee Lam PW, et al. Narrowband imaging system with magnifying endoscopy for rectal amyloidosis. Gastrointestinal Endoscopy. 2008;68(2):400-401. https://doi.org/10.1016/j.gie.2007.11.049.
33. Sattianayagam PT, Hawkins PN, Gillmore JD. Systemic amyloidosis and the gastrointestinal tract. Nat Rev Gastroenterol Hepatol. 2009;6(10):608-617. https://doi.org/10.1038/nrgastro.2009.147.
34. Koh Y. AL amyloidosis: advances in diagnosis and management. Blood Res. 2020;55:S54-S57. https://doi.org/10.5045/br.2020.S009.
35. Lysenko (Kozlovskaya) LV, Rameev VV, Moiseev SV, et al. Clinical practice guidelines for the diagnosis and treatment of systemic amyloidosis. Klinicheskaya farmakologiya i terapiya. 2020;29(1):13-24. https://doi.org/10.32756/ 0869-5490-2020-1-13-24. In Russian
36. Kapoor M, Rossor AM, Laura M, et al. Clinical Presentation, Diagnosis and Treatment of TTR Amyloidosis. J Neuromuscul Dis. 2019;6(2):189-199. https://doi.org/10.3233/jnd-180371.
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Solonitsyn E.G., Alieva I.Sh., Seyfedinova S.Sh., Baranov D.G., Mitrofanova L.B., Grozov R.V., Perminova A.A. Amyloidosis of the gastrointestinal tract. Clinical cases. Russian Journal for Personalized Medicine. 2021;1(1):237-253.
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ISSN 2782-3814 (Online)
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