Amyloidosis of the gastrointestinal tract. Clinical cases
Abstract
Amyloidosis is a group of diseases characterized by extracellular deposition of fibrillar protein (amyloid) in tissues and organs, consisting of β-sheet plates. The clinical manifestations and the endoscopic picture of amyloidosis are diverse and not very specific, which makes it difficult for specialists to make a diagnosis. The most common manifestations from the gastrointestinal tract are observed in AL-amyloidosis. The morphological diagnosis is made by detecting the characteristic apple-green birefringence in polarized light after staining with Congo red. This article presents clinical cases of diagnosis of amyloidosis of the gastrointestinal tract and modern literature data.
About the Authors
E. G. Solonitsyn
Almazov National Medical Research Centre; World-Class Research Centre for Personalized Medicine
Russian Federation
Russian Federation
Solonitsyn Evgeny G., PhD., Head of the Endoscopy Department, Associate Professor of the Department of Surgical Diseases with the Clinic; Head of the Research Laboratory of Oncological Diseases of the Digestive System
Saint Petersburg
Iu. Sh. Alieva
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Alieva Iuliia Sh., Endoscopist
Akkuratova str. 2, Saint Petersburg, Russia, 197341
S. Sh. Seyfedinova
World-Class Research Centre for Personalized Medicine
Russian Federation
Russian Federation
Seyfedinova Sabina Sh., Junior Researcher, Research Laboratory of Oncological Diseases of the Digestive System
Saint Petersburg
D. G. Baranov
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Baranov Dmitry G., Endoscopist, Gastroenterologist
Saint Petersburg
L. B. Mitrofanova
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Mitrofanova Lyubov B., MD, Dr. Sc., Pathomorphologist, Associate Professor, Head of the Research Laboratory of Pathomorphology, Chief Researcher of the Research Laboratory of Pathomorphology
Saint Petersburg
R. V. Grozov
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Grozov Roman V., PhD., Pathomorphologist
Saint Petersburg
A. A. Perminova
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Perminova Anastasia A., Pathomorphologist
Saint Petersburg
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Review
For citations:
Solonitsyn E.G., Alieva I.Sh., Seyfedinova S.Sh., Baranov D.G., Mitrofanova L.B., Grozov R.V., Perminova A.A. Amyloidosis of the gastrointestinal tract. Clinical cases. Russian Journal for Personalized Medicine. 2021;1(1):237-253.
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