Pseudothrombocytopenia — problems and ways to solve diagnostic problems
https://doi.org/10.18705/2782-3806-2023-3-4-38-43
Abstract
EDTA-dependent pseudothrombocytopenia is the laboratory phenomenon of a spurious low platelet count which appears in vitro while using EDTA as anticoagulant. The problem of EDTA-dependent pseudothrombocytopenia has significant relevance due to the widespread using of automated hematology analyzers which EDTA stabilized blood is most recommended for. The mechanism of this phenomenon is based on the production of the specificantibodies causing the platelet aggregation in the presence of EDTA. The aim of this study was to evaluate MgSO4 as an in vitro anticoagulant for platelet count, MPV and correction WBC. Early determination of the patients with EDTA-dependent pseudothrombocytopenia is an important diagnostic criterion necessary to exclude blood diseases and prevent errors in treatment.
About the Authors
M. N. ZeninaRussian Federation
Zenina Marina N. - Head of the Department of Morphological Research of the Center for Laboratory Research of the Clinic
Kirochnaya str., 41, Saint Petersburg, 191015
M. A. Nuzhdina
Russian Federation
Nuzhdina Maria A. - Doctor of Clinical Laboratory Diagnostics, Department of Morphological Research, Center for Laboratory Research Clinic
N. Y. Chernysh
Russian Federation
Chernysh Natalia Y. - PhD, Associate Professor of the Department of Laboratory Medicine with a clinic ; Doctor of Clinical Laboratory Diagnostics, Department of Morphological Research, Center for Laboratory Research Clinic
V. A. Yudina
Russian Federation
Yudina Victoria A. - PhD, Head of the Center for Laboratory Research of the Clinic; Associate Professor of the Department of Laboratory Medicine with the Clinic
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Review
For citations:
Zenina M.N., Nuzhdina M.A., Chernysh N.Y., Yudina V.A. Pseudothrombocytopenia — problems and ways to solve diagnostic problems. Russian Journal for Personalized Medicine. 2023;3(4):38-43. (In Russ.) https://doi.org/10.18705/2782-3806-2023-3-4-38-43