Clinical case of catheter-directed thrombolysis in cancer associated pulmonary embolism
https://doi.org/10.18705/2782-3806-2023-3-4-88-95
Abstract
Pulmonary embolism (PE) associated with malignant neoplasms is a frequent complication of the oncological process and leads to a decrease in survival and quality of life of these patients. In some cases, pulmonary embolism can become the debut of a current active oncological disease, which requires increased cancer alertness in patients with PE without clear predisposing factors, especially in cancer risk groups.
The article demonstrates a clinical case of an individualized approach to choosing an interventional strategy in a comorbid patient with high-risk PE. The tactics of active oncological screening made it possible to confirm a pulmonary embolism against the background of current prostate cancer.
Keywords
anticoagulant therapy,
cancer-associated venous thromboembolism,
catheter-directed thrombolysis,
hemorrhagic risk,
high risk,
intracranial hemorrhage,
pulmonary embolism,
prostate cancer,
ventricular failure
Supporting agencies: State task “Development of a decision support system for predicting the development of long-term outcomes of venous thromboembolic complications” (No. 121031100305-9)
About the Authors
S. I. Parkhomenko
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Parkhomenko Sofia I. - Clinical resident-cardiologist of the Department of Faculty Therapy with the clinic
Akkuratova str., 2, Saint Petersburg, 197341
T. D. Glebovskaya
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Glebovskaya Tatyana D. - Candidate of Medicine, Head of Anesthesiology and Intensive Care Unit no.6
Akkuratova str., 2, Saint Petersburg, 197341
K. N. Malikov
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Malikov Kirill N. - Junior researcher of Department for Vascular and Interventional Surgery, functional diagnostician
Akkuratova str., 2, Saint Petersburg, 197341
D. D. Zubarev
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Zubarev Dmitry D. - Candidate of Medicine, Head of the Department for X-ray Surgical Methods of Diagnosis and Treatment, researcher of Department for Vascular and Interventional Surgery
Akkuratova str., 2, Saint Petersburg, 197341
D. V. Alekseeva
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Alekseeva Daria V. - Head of Diagnostic Radiology Department No. 1, radiologist
Akkuratova str., 2, Saint Petersburg, 197341
M. A. Simakova
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Simakova Maria A. - Candidate of Medicine, Head, Senior Researcher at the National Research Institute of Cardio-Oncology, World-Class Research Centre for Personalized Medicine
Akkuratova str., 2, Saint Petersburg, 197341
References
1. Elyamany G, Alzahrani AM, Bukhary E. Cancer-associated thrombosis: an overview. Clin Med Insights Oncol. 2014 Dec 4;8:129–37. DOI: 10.4137/CMO.S18991. PMID: 25520567; PMCID: PMC4259501.
2. Gervaso L, Dave H, Khorana AA. Venous and Arterial Thromboembolism in Patients With Cancer: JACC: CardioOncology State-of-the-Art Review. JACC CardioOncol. 2021 Apr 20;3(2):173–190. DOI: 10.1016/j.jaccao.2021.03.001. PMID: 34396323; PMCID: PMC8352228.
3. Brose KM, Lee AY. Cancer-associated thrombosis: prevention and treatment. Curr Oncol. 2008 Jan;15(Suppl 1):S58–67. DOI: 10.3747/co.2008.177. PMID: 18231650; PMCID: PMC2216419.
4. Schulman S, Lindmarker P. Incidence of cancer after prophylaxis with warfarin against recurrent venous thromboembolism. Duration of Anticoagulation Trial. N Engl J Med. 2000 Jun 29;342(26):1953–8. DOI: 10.1056/NEJM200006293422604. PMID: 10874063.
5. Khorana AA, Francis CW, Culakova E, et al. Thromboembolism is a leading cause of death in cancer patients receiving outpatient chemotherapy. J Thromb Haemost. 2007 Mar;5(3):632–4. DOI: 10.1111/j.1538-7836.2007.02374.x. PMID: 17319909.
6. Gussoni G, Frasson S, La Regina M, et al. RIETE Investigators. Three-month mortality rate and clinical predictors in patients with venous thromboembolism and cancer. Findings from the RIETE registry. Thromb Res. 2013 Jan;131(1):24–30. DOI: 10.1016/j.thromres.2012.10.007. Epub 2012 Nov 8. PMID: 23141849.
7. Sørensen HT, Mellemkjaer L, Olsen JH, et al. Prognosis of cancers associated with venous thromboembolism. N Engl J Med. 2000 Dec 21;343(25):1846– 50. DOI: 10.1056/NEJM200012213432504. PMID: 11117976.
8. Zacharski LR, Wojtukiewicz MZ, Costantini V, et al. Pathways of coagulation/fibrinolysis activation in malignancy. Semin Thromb Hemost. 1992 Jan;18(1):104– 16. DOI: 10.1055/s-2007-1002415. PMID: 1574711.
9. Prandoni P, Lensing AW, Piccioli A, et al. Recurrent venous thromboembolism and bleeding complications during anticoagulant treatment in patients with cancer and venous thrombosis. Blood. 2002 Nov 15;100(10):3484–8. DOI: 10.1182/blood-2002-01-0108. Epub 2002 Jul 12. PMID: 12393647.
10. Konstantinides SV, Meyer G, Becattini C, et al. ESC Scientific Document Group, 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS): The Task Force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC), European Heart Journal, Volume 41, Issue 4, 21 January 2020, Pages 543–603, https://doi.org/10.1093/eurheartj/ehz405
11. Kim MS, Chang H, Lee SY, et al. Differential clinical manifestations and clinical outcome of cancerrelated pulmonary embolism. Korean J Intern Med. 2020 Mar;35(2):360–368. DOI: 10.3904/kjim.2018.267. Epub 2019 Aug 9. PMID: 31394894; PMCID: PMC7061009.
12. Kucher N, Boekstegers P, Müller OJ, et al. Randomized, controlled trial of ultrasound-assisted catheter-directed thrombolysis for acute intermediate-risk pulmonary embolism. Circulation. 2014 Jan 28;129(4):479–86. DOI: 10.1161/CIRCULATIONAHA.113.005544. Epub 2013 Nov 13. PMID: 24226805.
13. Kuo WT, Banerjee A, Kim PS, et al. Pulmonary Embolism Response to Fragmentation, Embolectomy, and Catheter Thrombolysis (PERFECT): Initial Results From a Prospective Multicenter Registry. Chest. 2015 Sep;148(3):667–673. DOI: 10.1378/chest.15-0119. PMID: 25856269.
14. Piazza G, Hohlfelder B, Jaff MR, et al. SEATTLE II Investigators. A Prospective, Single-Arm, Multicenter Trial of Ultrasound-Facilitated, Catheter-Directed, Low-Dose Fibrinolysis for Acute Massive and Submassive Pulmonary Embolism: The SEATTLE II Study. JACC Cardiovasc Interv. 2015 Aug 24;8(10):1382–1392. DOI: 10.1016/j.jcin.2015.04.020. PMID: 26315743.
Review
For citations:
Parkhomenko S.I., Glebovskaya T.D., Malikov K.N., Zubarev D.D., Alekseeva D.V., Simakova M.A. Clinical case of catheter-directed thrombolysis in cancer associated pulmonary embolism. Russian Journal for Personalized Medicine. 2023;3(4):88-95. (In Russ.) https://doi.org/10.18705/2782-3806-2023-3-4-88-95
Views:
281
Email this article 