Влияние флавоноидов на пролиферацию и остеогенную дифференцировку интерстициальных клеток аортального клапана

Во всем мире идет поиск терапевтического лечения кальцифицирующей болезни аортального клапана (аортального стеноза), лечение которой сейчас производится только с помощью хирургического вмешательства. Фундаментальные молекулярно-биологические исследования помогают в поиске антикальцифицирующей терапии, и нами ведутся исследования по поиску терапевтического лечения кальцификации аортального клапана. В данной работе представлено исследование флавоноидов, потенциальных веществ для антикальцифицирующей терапии.

1. Writing Group Members, Mozaffarian D, Benjamin EJ, Go AS, et al. Heart Disease and Stroke Statistics-2016 Update: A Report From the American Heart Association. Circulation. 26 Jan 2016;133(4):e38-360.

2. Kanwar A, Thaden JJ, Nkomo VT. Management of Patients With Aortic Valve Stenosis. Mayo Clin Proc. Apr 2018;93(4):488–508.

3. Lee G, Chikwe J, Milojevic1 M, et al. ESC/EACTS vs. ACC/AHA guidelines for the management of severe aortic stenosis. Eur Heart J. 7 Mar 2023;44(10):796–812.

4. Kachanova O, Lobov A, Malashicheva A. The Role of the Notch Signaling Pathway in Recovery of Cardiac Function after Myocardial Infarction. Int J Mol Sci. 19 Oct 2022;23(20):12509.

5. Kostina A, Bjork H, Ignatieva E, et al. Notch, BMP and WNT/β-catenin network is impaired in endothelial cells of the patients with thoracic aortic aneurysm. Atheroscler Suppl. Sep 2018;35:e6–13.

6. Kostina A, Shishkova A, Ignatieva E, et al. Different Notch signaling in cells from calcifi bicuspid and tricuspid aortic valves. J Mol Cell Cardiol. Jan 2018;114:211–9.

7. Kozyrev I, Dokshin P, Kostina A, et al. Dysregulation of Notch signaling in cardiac mesenchymal cells of patients with tetralogy of Fallot. Pediatr Res. Jul 2020;88(1):38–47.

8. Malashicheva A, Kostina A, Kostareva A, et al. Notch signaling in the pathogenesis of thoracic aortic aneurysms: A bridge between embryonic and adult states. Biochim Biophys Acta Mol Basis Dis. 1 Mar 2020;1866(3):165631.

9. de Oliveira Sá MPB, Cavalcanti LRP, Perazzo ÁM, et al. Calcific Aortic Valve Stenosis and Atherosclerotic Calcification. Curr Atheroscler Rep. 7 Jan 2020;22(2):2.

10. Garg V. Notch Signaling in Aortic Valve Development and Disease. В: Nakanishi T, Markwald RR, Baldwin HS, Keller BB, Srivastava D, Yamagishi H, editors. Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology [Интернет]. Tokyo: Springer; 2016 [цитируется по 27 февраль 2024 г.]. Доступно на: http://www.ncbi.nlm.nih.gov/books/NBK500291/

11. Irtyuga O, Malashicheva A, Zhiduleva E, et al. NOTCH1 Mutations in Aortic Stenosis: Association with Osteoprotegerin/RANK/RANKL. Biomed Res Int. 2017;2017:6917907.

12. Lee A, Wei S, Schwertani A. A Notch more: Molecular players in bicuspid aortic valve disease. J Mol Cell Cardiol. Sep 2019;134:62–8.

13. Semenova D, Bogdanova M, Kostina A, et al. Dose-dependent mechanism of Notch action in promoting osteogenic differentiation of mesenchymal stem cells. Cell Tissue Res. Jan 2020;379(1):169–79.

14. Singh AK, Kumar S. Flavonoids as emerging notch signaling pathway modulators in cancer. J Asian Nat Prod Res. Dec 2023;25(12):1155–67.

15. Rutkovskiy A, Malashicheva A, Sullivan G, et al. Valve Interstitial Cells: The Key to Understanding the Pathophysiology of Heart Valve Calcification. J Am Heart Assoc. 14 Sep 2017;6(9):e006339.

16. Boyarskaya NV, Shishkova AA, Saprankov VL, et al. Features of collecting biological material in the study of pathological calcification of the heart and blood vessels. jour. 13 Jul 2022;2(3):111–8.

17. Chiorcea-Paquim AM. Electrochemistry of Flavonoids: A Comprehensive Review. Int J Mol Sci. 27 Oct 2023;24(21):15667.

18. Gupta M, Ahmad J, Ahamad J, et al. Flavonoids as promising anticancer therapeutics: Contemporary research, nanoantioxidant potential, and future scope. Phytother Res. Nov 2023;37(11):5159–92.

19. Luiz-Ferreira A, Pacifico T, Cruz ÁC, et al. TRAILSensitizing Effects of Flavonoids in Cancer. Int J Mol Sci. 22 Nov 2023;24(23):16596.

20. Hassani S, Maghsoudi H, Fattahi F, et al. Flavonoids nanostructures promising therapeutic efficiencies in colorectal cancer. Int J Biol Macromol. 30 Jun 2023;241:124508.

21. Ma EZ, Khachemoune A. Flavonoids and their therapeutic applications in skin diseases. Arch Dermatol Res. Apr 2023;315(3):321–31.

22. Kothawade SM, Buttar HS, Tuli HS, Kaur G. Therapeutic potential of flavonoids in the management of obesity-induced Alzheimer’s disease: an overview of preclinical and clinical studies. Naunyn Schmiedebergs Arch Pharmacol. Nov 2023;396(11):2813–30.

23. Chen S, Wang X, Cheng Y, et al. A Review of Classification, Biosynthesis, Biological Activities and Potential Applications of Flavonoids. Molecules. 25 Jun 2023;28(13):4982.