The effect of flavonoids on the proliferation and osteogenic differentiation of interstitial cells of the aortic valve
https://doi.org/10.18705/2782-3806-2024-4-3-206-214
EDN: KZPIGA
Abstract
There is a worldwide search for therapeutic treatment of calcification aortic valve disease (aortic stenosis), which is currently being treated only with surgical intervention. Fundamental molecular biological research helps in the search for anticalcification therapy and we are conducting research to find a therapeutic treatment for aortic valve calcification. This paper presents a study of flavonoids, potential substances for anticalcification therapy.
About the Authors
N. V. Boyarskaya
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Boyarskaya Nadejda V., junior researcher, Laboratory of diseases with excessive calcification, World-Class Research Centre for Personalized
Akkuratova str., 2, Saint Petersburg, Russia, 197341
O. I. Skortsanu
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Skortsanu Olga I., laboratory assistant researcher, Neuromodulation Laboratory, World-Class Research Centre for Personalized Medicine
Akkuratova str., 2, Saint Petersburg, Russia, 197341
P. M. Dokshin
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Dokshin Pavel M., junior researcher, Laboratory of diseases with excessive calcification, World-Class Research Centre for Personalized Medicine
Akkuratova str., 2, Saint Petersburg, Russia, 197341
V. E. Uspensky
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Uspensky Vladimir E., D. of Sc., Head Laboratory of Aortic and Aortic Valve Diseases of the Institute of Heart and Blood Vessels
Akkuratova str., 2, Saint Petersburg, Russia, 197341
T. S. Shcherbinin
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Shcherbinin Timofey S., junior researcher, Laboratory of diseases with excessive calcification, World-Class Research Centre for Personalized Medicine
Akkuratova str., 2, Saint Petersburg, Russia, 197341
A. A. Filippov
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Filippov Aleksey A., junior researcher, Laboratory of diseases with excessive calcification, World-Class Research Centre for Personalized Medicine
Akkuratova str., 2, Saint Petersburg, Russia, 197341
A. S. Pishchugin
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Pishchugin Aleksander S., Laboratory of diseases with excessive calcification, World-Class Research Centre for Personalized Medicine
Akkuratova str., 2, Saint Petersburg, Russia, 197341
I. V. Galyautdinov
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Pishchugin Aleksander S., Laboratory of diseases with excessive calcification, World-Class Research Centre for Personalized Medicine
Akkuratova str., 2, Saint Petersburg, Russia, 197341
A. B. Malashicheva
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Malashicheva Anna B., Leading scientist, D. of Sc., Laboratory of diseases with excessive calcification, World-Class Research Centre for Personalized Medicine
Akkuratova str., 2, Saint Petersburg, Russia, 197341
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Review
For citations:
Boyarskaya N.V., Skortsanu O.I., Dokshin P.M., Uspensky V.E., Shcherbinin T.S., Filippov A.A., Pishchugin A.S., Galyautdinov I.V., Malashicheva A.B. The effect of flavonoids on the proliferation and osteogenic differentiation of interstitial cells of the aortic valve. Russian Journal for Personalized Medicine. 2024;4(3):206-214. (In Russ.) https://doi.org/10.18705/2782-3806-2024-4-3-206-214. EDN: KZPIGA
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