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Personalised approach to combined treatment of nasopharyngeal cancer (case report)

https://doi.org/10.18705/2782-3806-2024-4-4-329-339

EDN: CVGBBQ

Abstract

   Superselective chemoembolization (SC) is currently a promising method for the treatment of the head and neck cancer. We describe a clinical case of successful combined (SC+ general chemotherapy) treatment of malignant nasopharyngeal neoplasm in a 40­year­old patient with bilateral spread ofT4N2­3M0, resulting in hearing loss on both sides, significant difficulty in nasal breathing and complicated by nasal bleeding. Quality of life of the patient improved significantly.

About the Authors

V. G. Voronov
Polenov Russian Scientific Research Institute of Neurosurgery — branch of the Almazov National Medical Research Centre
Russian Federation

Viktor G. Voronov, Doctor of Medical Sciences, Higher Researcher, neurosurgeon

Research Laboratory of Brain and Spinal Cord

Saint Petersburg



S. D. Radjabov
Polenov Russian Scientific Research Institute of Neurosurgery — branch of the Almazov National Medical Research Centre
Russian Federation

Saidakhmed D. Radjabov, Candidate of Medical Sciences, Associate Professor, Leading Researcher, Neurosurgeon

Department of Neurosurgery; Research Laboratory of the Brain and Spinal Cord, Department of Neurosurgery of the Vessels of the Brain and Spinal Cord

191014; Mayakovskaya str., 12; Saint Petersburg



A. A. Ivanov
Polenov Russian Scientific Research Institute of Neurosurgery — branch of the Almazov National Medical Research Centre
Russian Federation

Arkadiy A. Ivanov, Candidate of Medical Sciences, Senior Researcher, neurosurgeon

Research Laboratory of the Brain and Spinal Cord

Saint Petersburg



S. G. Ismailov
Polenov Russian Scientific Research Institute of Neurosurgery — branch of the Almazov National Medical Research Centre
Russian Federation

Sultan G. Ismailov, Resident

Department of Neurosurgery

Saint Petersburg



References

1. Spirin DS, Kobyakov GL, Cherekaev VA, et al. Epidemiology, diagnosis, clinical symptoms, and classification of malignant primary skull base tumors. Voprosy neirokhirurgii imeni NN Burdenko. 2016;80(3):106. In Russian doi: 10.17116/neiro2016803106-113

2. Moshurov IP, Redkin AN, Znatkova NA, et al. Long-lastingfull remission after selective intra-arterial chemotherapy for recurrence of locally advanced oral mucosa carcinoma. Practical oncology. 2019;20(4):336–42. In Russian doi: 10.31917/2004336

3. Olshansky MS, Moshurov IP, Zolotykh TM, al. The significance of selective intra-arterial interventions for palliation care in malignant head and neck tumors. Palliative Medicine and Rehabilitation. 2020:26–33. In Russian

4. Radzhabov SD, Voronov VG, Ivanov AA, Rasulov ZM. Endovascular superselective chemoembolization in a personalized approach to the treatment of patients with hypervascularized head and neck tumors complicated by nasal bleeding. Professor AL Polenov Russian Journal of Neurosurgery. 2022;14:122–127. In Russian

5. Radzhabov SD, Ivanov AA, Voronov VG. Modern aspect of the approach to diagnosis and treatment of locally advanced malignant neoplasms of the head and neck (Literature Review). Professor AL Polenov Russian Journal of Neurosurgery. 2021;13:79–84. In Russian

6. Voronov VG, Radzhabov SD, Ivanov AA, Rasulov ZM. Efficacy of endovascular superselective chemoembolization with HepaSphere 50–100 μm microspheres saturated with cytostatic in stopping nosebleeds in patients with nasopharyngeal cancer. Grekov’s Bulletin of Surgery. 2022;181(2):11–5. In Russian doi: 10.24884/0042-4625-2022-181-2-11-15

7. Cherekaev VA, Golbin DA, GasparyanTG, et al. Management of Craniofacial Chondroid Tumors. J Craniofac Surg. 2015;26(1):10–8. In Russian doi: 10.1097/SCS.0000000000001307

8. Radzhabova ZA, Radzhabov, SD, Kotov MA, et al. Method of combined treatment of locally spread malignant neoplasms of nasopharynx. 2021. In Russian

9. Voronov VG, Radzhabov SD, Ivanov AA, Radzhabova ZA. Superselective chemoembolization in a personalized approach to diagnosis and combined treatment of metastases of locally-spread hypervascularized malignancies of the head and neck. Russian Neurosurgical Journal of Prof AL Polenov. 2021;13:22–28. In Russian

10. Bronstein BL, Khojaev VG. Regional intra-arterial chemotherapy for cancers of maxillofacial localization. Voprosy Onkologii = Problems in Oncology. 1964:8–14. In Russian

11. Nakasato T, Katoh K, Sone M, et al. Superselective Continuous arterial infusion chemotherapy through the superficial temporal artery for oral cavity tumors. AJNR Am J Neuroradiol. 2000;21(10):1917–22.

12. Mitrofanov AS, Rad-Jabova ZA-G, Radjabov SD, et al. Results of treatment of patients with nasopharyngeal malignancies after superselective chemoembolization of tumor vessels. Voprosy Onkologii = Problems in Oncology. 2023;69(3):487–496. In Russian


Review

For citations:


Voronov V.G., Radjabov S.D., Ivanov A.A., Ismailov S.G. Personalised approach to combined treatment of nasopharyngeal cancer (case report). Russian Journal for Personalized Medicine. 2024;4(4):329-339. (In Russ.) https://doi.org/10.18705/2782-3806-2024-4-4-329-339. EDN: CVGBBQ

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ISSN 2782-3806 (Print)
ISSN 2782-3814 (Online)