Динамическое наблюдение изменения репертуара антител против грибковых углеводных антигенов в сыворотке крови человека

Микроскопические представители царства грибов широко распространены в окружающей среде и составляют значимую часть естественной микробиоты человека. В то же время при определенных условиях комменсальные виды грибов способны выступать в роли оппортунистических патогенов и вызывать заболевания различной степени тяжести, включая тяжелые и потенциально смертельные инвазивные микозы. Возможность реализации патогенного потенциала микроорганизма в значительной степени зависит от индивидуальных особенностей иммунной системы хозяина и параметров его иммунного ответа. В данной работе с использованием панели синтетических олигосахаридов, структурно родственных иммунодетерминантным фрагментам полисахаридных антигенов клеточных стенок различных видов грибов, проведен анализ репертуара специфичности антигрибковых антител сыворотки крови человека. В результате исследования установлено выраженное межиндивидуальное разнообразие антительных профилей при сохранении относительной стабильности индивидуального профиля при анализе в динамике в течение двух лет. Полученные результаты указывают на потенциал использования профиля специфичности антител к грибковым антигенам в качестве персонализированного иммунологического дескриптора противогрибкового иммунного ответа для диагностики и мониторинга грибковых заболеваний, а также оценки нарушений иммунной системы.

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