Malignant trophoblastic disease: a rare tumor requiring personalized treatment. Stateof-the-art
https://doi.org/10.18705/2782-3806-2022-2-4-44-55
Abstract
Gestational trophoblastic disease (GTD) is a rare tumor characterized by spectrum of trophoblastic proliferative disorders associated with pregnancy. These neoplasms occur in less than 1% of female genital malignancies. There is a high curability of the disease even in the presence of disseminated process with the ability to preserve reproductive function. However, this is possible if timely diagnosis and adequate treatment tactics were applied. The article presents a review of the literature and the summary of guidelines of treatment of this malignancy.
Keywords
atypical placental site nodule,
choriocarcinoma,
complete hydatidiform mole,
epithelioid trophoblastic tumor,
gestational trophoblastic disease,
invasive hydatidiform mole,
partial hydatidiform mole,
trophoblastic neoplasia
Supporting agencies: This work was financially supported by the Ministry of Science and Higher Education of the Russian Federation (Agreement No. 075-15-2022-301)
About the Authors
E. A. Ulrikh
Almazov National Medical Research Centre, World-Class Research Centre for Personalized Medicine;
N. N. Petrov National Medical Research Centre of Oncology
Russian Federation
Russian Federation
Ulrikh Elena A., Medical Science Doctor, Professor, Head of the Scientific Research Laboratory of Oncogynecology Almazov National Medical Research Centre, Professor of the Department of Oncology, N. N. Petrov National Medical Research Centre of Oncology
Akkuratova str., 2, Saint Petersburg, 197341
E. L. Dikareva
Almazov National Medical Research Centre, World-Class Research Centre for Personalized Medicine
Russian Federation
Russian Federation
Dikareva Elena L., PhD, Senior Researcher of the Scientific Research Laboratory of Oncogynecology World-Class Research Centre for Personalized Medicine
Saint Petersburg
O. A. Zhamborova
Almazov National Medical Research Centre, World-Class Research Centre for Personalized Medicine
Russian Federation
Russian Federation
Zhamborova Oksana A., junior researcher of the Scientific Research Laboratory of Oncogynecology World-Class Research Centre for Personalized Medicine
Saint Petersburg
A. D. Dzharbaeva
Almazov National Medical Research Centre, World-Class Research Centre for Personalized Medicine
Russian Federation
Russian Federation
Dzharbaeva Aminat D., junior researcher of the Scientific Research Laboratory of Oncogynecology World-Class Research Centre for Personalized Medicine
Saint Petersburg
T. M. Pervunina
Almazov National Medical Research Centre, World-Class Research Centre for Personalized Medicine
Russian Federation
Russian Federation
Pervunina Tatyana M., Medical Science Doctor, Director of the Institute of Perinatology and Pediatrics
Saint Petersburg
E. V. Komlichenko
Almazov National Medical Research Centre, World-Class Research Centre for Personalized Medicine
Russian Federation
Russian Federation
Komlichenko Eduard V., Medical Science Doctor, Deputy Chief for Oncology, Professor of the Department of Organization, Management and Economics of Healthcare, Institute of Medical Education
Saint Petersburg
S. A. Protsenko
N. N. Petrov National Medical Research Centre of Oncology
Russian Federation
Russian Federation
Protsenko Svetlana A., Head of the Department of Chemotherapy and Innovative Technologies, Leading researcher
Saint Petersburg
G. M. Teletaeva
N. N. Petrov National Medical Research Centre of Oncology
Russian Federation
Russian Federation
Teletaeva Gulfiya M., Senior Researcher of the Department of Chemotherapy and Innovative Technologies
Saint Petersburg
O. A. Lee
Almazov National Medical Research Centre, World-Class Research Centre for Personalized Medicine
Russian Federation
Russian Federation
Lee Olga A., PhD, Deputy Chief of the Perinatal Clinic of the Institute of Perinatology
Saint Petersburg
N. A. Osipova
Almazov National Medical Research Centre, World-Class Research Centre for Personalized Medicine
Russian Federation
Russian Federation
Osipova Natalia A., Medical Science Doctor, Head of the Department of Pathology of pregnant women
Saint Petersburg
I. E. Zazerskaya
Almazov National Medical Research Centre, World-Class Research Centre for Personalized Medicine
Russian Federation
Russian Federation
Zazerskaya Irina E., Medical Science Doctor, professor, Head of the Department of Obstetrics and Gynecology
Saint Petersburg
I. E. Govorov
Almazov National Medical Research Centre, World-Class Research Centre for Personalized Medicine
Russian Federation
Russian Federation
Govorov Igor E., PhD, Senior researcher of the Scientific Research Laboratory of Oncogynecology World-Class Research Centre for Personalized Medicine, Almazov National Medical Research Centre, Head of the Scientific Research Laboratory of operative gynecology
Saint Petersburg
A. Z. Baksanova
Almazov National Medical Research Centre, World-Class Research Centre for Personalized Medicine
Russian Federation
Russian Federation
Baksanova Amina Z., assistant researcher of the Scientific Research Laboratory of Oncogynecology World-Class Research Centre for Personalized Medicine
Saint Petersburg
I. A. Mashchenko
Almazov National Medical Research Centre, World-Class Research Centre for Personalized Medicine
Russian Federation
Russian Federation
Mashchenko Irina A., The head of the group of the NIG of Radiation Research Methods in Perinatology and Pediatrics, assistant of the Department of Radiation Diagnostics and Medical Imaging of the Institute of Medical Education
Saint Petersburg
E. D. Vyshedkevich
Almazov National Medical Research Centre, World-Class Research Centre for Personalized Medicine
Russian Federation
Russian Federation
Vyshedkevich Elena D., assistant researcher of the Department of Radiation Diagnostics and Medical Imaging of the Institute of Medical Education
Saint Petersburg
A. F. Urmancheeva
N. N. Petrov National Medical Research Centre of Oncology
Russian Federation
Russian Federation
Urmancheeva Adilia F., Doctor of Medical Sciences, Leading researcher of N. N. Petrov National Medical Research Centre of Oncology, Professor of the Department of Oncology North-Western State Medical University named after I. I. Mechnikov, Honored Doctor of Russia, President of the Russian Society of Gynecology and Oncology
Saint Petersburg
T. Y. Semiglazova
N. N. Petrov National Medical Research Centre of Oncology
Russian Federation
Russian Federation
Semiglazova Tatyana Yu., Medical Science Doctor, Head of the Scientific Department of Innovative Methods of Therapeutic Oncology and Rehabilitation, Leading Researcher of N. N. Petrov National Medical Research Centre of Oncology, Professor of the Department of Oncology North-Western State Medical University named after I. I. Mechnikov
Saint Petersburg
References
1. Ning F, Hou H, Morse AN, Lash GE. Understanding and management of gestational trophoblastic disease. F1000Res. 2019 Apr 10;8:F1000 Faculty Rev-428.
2. Female Genital Tumours WHO Classification of Tumours, 5th Edition, Volume 4.
3. Tidy J, Seckl M, Hancock BW, on behalf of the Royal College of Obstetricians and Gynaecologists. Management of Gestational Trophoblastic Disease. BJOG 2021;128:e1–e27.
4. AlazzamM, Tidy J, Osborne R, Coleman R, Hancock BW, Lawrie TA Chemotherapy for Resistant or Recurrent Gestational Trophoblastic Neoplasia Cochrane Database of Systematic Reviews 2016, Issue 1. Art. No.: CD008891.
5. Ульрих Е.А., Телетаева Г.М., Латипова Д.Х., Семенова А.И., Левченко Е.В., Ульрих Д.Г., Берлев И.В., Семиглазова Т.Ю., Проценко С.А., Урманчеева А.Ф. Индивидуализация в лечении резистентных форм гестационной трофобластической неоплазии Вопросы онкологии, 2020. Том 66, № 6: 667–672.
6. Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L. Update on the diagnosis and management of gestational trophoblastic disease. Int J Gynaecol Obstet. 2018 Oct;143 Suppl 2:79–85.
7. Жарова А.С., Мещерякова Л.А., Масленников А.Ф., Кузнецов В.В., Козаченко В.П., Давыдова И.Ю., Мещеряков А.А. Современные возможности лечения резистентных трофобластических опухолей и рецидивов. Доктор.Ру. 2020; 19(1): 55–61.
8. Телетаева Г.М., Ульрих Е.А., Латипова Д.Х., Семенова А.И., Левченко Е.В., Ульрих Д.Г., Берлев И.В., Семиглазова Т.Ю., Проценко С.А., Урманчеева А.Ф. Успешный опыт лечения гестационной трофобластической неоплазии высокого риска у пациентки с непереносимостью стандартной химиотерапии (клинический случай). Опухоли женской репродуктивной системы, 2020. — Том 16, № 3. — С. 67–71.
9. Bolze P-A, Patrier S, Massardier J, et al. PD-L1 expression in premalignant and malignant trophoblasts from gestational trophoblastic diseases is ubiquitous and independent of clinical outcomes. Int J Gynecol Cancer 2017; 27: 554–61.
10. You B, Bolze PA, Lotz JP, Massardier J et al. Gladieff L, Joly F, Hajri T, Maucort-Boulch D, Bin S, Rousset P, Villeneuve L, Roux A, Alves-Ferreira M, Grazziotin D, Mercier C, Freyer G, Golfier F // Avelumab in patients with gestational trophoblastic tumors resistant to monochemotherapy: Final outcomes of TROPHIMMUN phase II trial, cohort A // J Clin Oncol 38: 2020 (suppl; abstr LBA6008).
Review
For citations:
Ulrikh E.A., Dikareva E.L., Zhamborova O.A., Dzharbaeva A.D., Pervunina T.M., Komlichenko E.V., Protsenko S.A., Teletaeva G.M., Lee O.A., Osipova N.A., Zazerskaya I.E., Govorov I.E., Baksanova A.Z., Mashchenko I.A., Vyshedkevich E.D., Urmancheeva A.F., Semiglazova T.Y. Malignant trophoblastic disease: a rare tumor requiring personalized treatment. Stateof-the-art. Russian Journal for Personalized Medicine. 2022;2(4):44-55. (In Russ.) https://doi.org/10.18705/2782-3806-2022-2-4-44-55
Views:
654
Email this article 