Synthesis of micro- and nanoparticles in microfluid reactors for biomedical applications
Abstract
Currently, microfluidic devices are striving for implementation in many areas of biomedicine: drug synthesis, theranostics, biosensors. Such devices provide fast and sufficient mixing in microfluidic channels, make it possible to obtain monodisperse particles, including nanoscale ones, to control the synthesis conditions and to precisely regulate the physicochemical properties of the resulting substances. Sensors based on microfluidics allow detecting various pathological processes. The presented review gives an idea of the principles of constructing microflow devices, chip materials, and reagent dosing systems. Examples of the use of microfluidics in various fields are given.
About the Authors
E. O. Lazareva
Almazov National Medical Research Centre; Saint Petersburg Electrotechnical University “LETI”
Russian Federation
Russian Federation
Lazareva Elizaveta O., Junior Researcher of the Research Laboratory of Nanotechnology, Center for Experimental Biomodelling, Institute of Experimental Medicine
Akkuratova str. 2, Saint Petersburg, Russia, 197341
A. A. Evstrapov
Institute for Analytical Instrumentation Russian Academy of Science
Russian Federation
Russian Federation
Evstrapov Anatoly A. Dr. Sci., Acting Director
Saint Petersburg
K. G. Gareev
Saint Petersburg Electrotechnical University “LETI”
Russian Federation
Russian Federation
Gareev Kamil G., PhD, Associate Professor, Micro and Nanoelectronics Department
Saint Petersburg
Yu. V. Cheburkin
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Cheburkin Yuri V., PhD, Head of the Research Laboratory of Contagious and Biomolecular Nanostructures, Center for Preclinical Translational
Saint Petersburg
A. Krizhanovich
Saint Petersburg Electrotechnical University “LETI”
Russian Federation
Russian Federation
Krizhanovich Alexander, Master’s student
Saint Petersburg
D. V. Korolev
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Korolev Dmitrii V., Dr. Sci., Head of the Research Laboratory of Nanotechnology, Center for Experimental Biomodelling, Institute of Experimental Medicine
Saint Petersburg
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Review
For citations:
Lazareva E.O., Evstrapov A.A., Gareev K.G., Cheburkin Yu.V., Krizhanovich A., Korolev D.V. Synthesis of micro- and nanoparticles in microfluid reactors for biomedical applications. Russian Journal for Personalized Medicine. 2021;1(1):207-236.
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