Молекулярные механизмы лекарственной устойчивости глиобластомы: дифференцировка и апоптоз

Глиобластомы (ГБМ) представляют одну из самых злокачественных и частых опухолей человека, характеризующихся быстрым ростом, метастазированием, устойчивостью к методам терапии и образованием рецидивов. Формирование в клетках ГБМ механизмов множественной лекарственной устойчивости (МЛУ) часто сочетается с ингибированием путей клеточной гибели, дифференцировки и препятствует увеличению эффективности терапии этой группы пациентов. В обзоре рассматривается взаимосвязь молекулярных механизмов МЛУ с дифференцировкой и апоптозом ГБМ с акцентом на выявление новых мишеней среди белков, микроРНК, генов-супрессоров и онкогенов.

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