Adult-onset familial mediterranean fever: case reports with literature review
https://doi.org/10.18705/2782-3806-2024-4-5-452-457
EDN: RMJMYU
Abstract
Familial Mediterranean Fever (FMF) is a rare monogenic autoinflammatory disease that typically manifests in early childhood. The disease is characterized by its prevalence within a specific ethnic group. Nevertheless, FMF can also manifest in later stages of life among individuals with or without an ethnic background. We present two case reports of FMF patients, where the onset of the disease occurred in the third decade of life. These cases emphasize the importance of including monogenic autoinflammatory diseases in the differential diagnosis of adults presenting with fever of unknown origin and exhibiting typical FMF symptoms regardless of ethnicity.
Keywords
adult-onset,
autoinflammatory disease,
Familial Mediterranean Fever,
fever of unknown origin,
MEFV,
periodic fever
Supporting agencies: This work was financially supported by the Ministry of Science and Higher Education of the Russian Federation (Agreement No. 075-15-2022-301 date of agreement 04/20/2022)
About the Authors
V. Yu. Myachikova
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Maslyanskiy Alexey L. - PhD, MD, Rheumatologist, Professor of the Department of Faculty Therapy with the clinic of Medical Education; Head of the department “Research Laboratory of Rheumatology and immunopathology”, Almazov NMRC; Professor of the Scientific, Clinical and Educational Centre of Gastroenterology and Hepatology, Saint-Petersburg SU.
Akkuratova str., 2, Saint Petersburg, 197341
K. A. Aksenova
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Aksenova Ksenia A. - 6th year student of the Institute of Medical Education.
Saint-Petersburg
A. A. Khodot
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Khodot Anna A. - 6th year student of the Institute of Medical Education.
Saint-Petersburg
A. L. Maslyanskiy
Almazov National Medical Research Centre; Saint Petersburg State University
Russian Federation
Russian Federation
Myachikova Valentina Yu. - PhD, Rheumatologist, Professor assistant of the Department of Faculty Therapy with the clinic of Medical Education; a researcher World-Class Research Centre for Personalized Medicine, Rare and Genetically Determined Diseases, Research Laboratory of Autoimmune and Autoinflammatory Diseases.
Saint-Petersburg
References
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Review
For citations:
Myachikova V.Yu., Aksenova K.A., Khodot A.A., Maslyanskiy A.L. Adult-onset familial mediterranean fever: case reports with literature review. Russian Journal for Personalized Medicine. 2024;4(5):452-457. (In Russ.) https://doi.org/10.18705/2782-3806-2024-4-5-452-457. EDN: RMJMYU
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