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EVALUATION OF STRUCTURAL FND FUNCTIONAL FEATURES OF REIMPLANTED AORTIC VALVE AFTER DAVID I PROCEDURE WITH THE USE OF HIGH-PRECISSION 3-DIMENSIONAL SEGMENTATION OF THE AORTIC ROOT

https://doi.org/10.18705/2782-3806-2022-2-3-78-88

Abstract

Aneurysm of the aortic root accompanied by aortic insufficiency is a common cardiovascular pathology. The optimal method of surgical treatment of this pathology is the reimplantation of the aortic valve into the aortic root synthetic prosthesis (David procedure). Currently, there is no comprehensive data on the influence of initial geometric parameters of the aortic root structures on the functioning of the reimplanted aortic valve after valve-preserving aortic root replacement. We have introduced a novel technique for creation and segmentation of a three-dimensional reconstruction of the aortic valve and root, which involves the sequential application of two computer-aided design environments: In Vesalius v 3.1.1 (Centro de Tecnologia da Informação Renato Archer (CTI)) and 3- Matic v. 13.0 (Materialise, Leuven, Belgium). The proposed method allows accurate measurement and evaluation of spatial parameters of the AV leaflets, fibrous ring, sinuses of Valsalva and sinotubular junction. The developed technique was used to evaluate the anatomical and functional features of the aortic valve in a 68-year-old patient who underwent David I procedure. Segmentation and measurement of the geometric parameters of the aortic root were performed before operation, as well as 18 months after surgical treatment. To assess the function of the reimplanted aortic valve during the long-term follow-up, a detailed echocardiographic assessment was used. Echocardiographic assessment included measuring volume and area of the regurgitation flow, the width of vena contracta, and the regurgitation fraction. The application of high-precision 3D reconstruction opens up additional opportunities in the field of surgical treatment of the aortic root and AV pathology: advantages in choosing an individual patient-oriented surgical tactics, parameters of the implanted surgical material and/or device, and in predicting long-term results of surgical treatment.

About the Authors

A. A. Filippov
Almazov National Medical Research Centre, World-Class Research Centre for Personalized Medicine
Russian Federation

Filippov Aleksei A., Researcher of the Research Laboratory of diseases with excessive calcification

Akkuratova str., 2, Saint Petersburg, 197341



V. E. Uspenskiy
Almazov National Medical Research Centre, World-Class Research Centre for Personalized Medicine
Russian Federation

Uspenskiy Vladimir E., MD, PhD, Head of the Research Laboratory of the aorta and aortic valve diseases

Akkuratova str., 2, Saint Petersburg, 197341



G. A. Grubenko
“Koshelek.ru” Company
Russian Federation

Grubenko Grigorii A., Specialist for digital software testing

Saint Petersburg



D. S. Тolpygin
Almazov National Medical Research Centre, World-Class Research Centre for Personalized Medicine
Russian Federation

Tolpygin Dmitry S., PhD, Cardiothoracic surgeon of the Department of cardio-thoracic surgery 

Akkuratova str., 2, Saint Petersburg, 197341



E. A. Karev
Almazov National Medical Research Centre, World-Class Research Centre for Personalized Medicine
Russian Federation

Karev Egor A., Researcher of the Research Laboratory of the aorta and aortic valve diseases

Akkuratova str., 2, Saint Petersburg, 197341



P. A. Kvindt
Almazov National Medical Research Centre, World-Class Research Centre for Personalized Medicine
Russian Federation

Kvindt Pavel A., Researcher of the Research Laboratory of diseases with excessive calcification

Akkuratova str., 2, Saint Petersburg, 197341



P. V. Ananyevskaya
Almazov National Medical Research Centre, World-Class Research Centre for Personalized Medicine
Russian Federation

Ananyevskaya Polina V., Senior researcher at Biostatistics laboratory

Akkuratova str., 2, Saint Petersburg, 197341



A. O. Kolodiazhnaya
Almazov National Medical Research Centre, World-Class Research Centre for Personalized Medicine
Russian Federation

Kolodyazhnaya Alina O., Clinical Resident of the Department of Obstetrics and Gynecology

Akkuratova str., 2, Saint Petersburg, 197341



A. B. Malashicheva
Almazov National Medical Research Centre, World-Class Research Centre for Personalized Medicine
Russian Federation

Malashicheva Anna B., PhD, Senior Researcher of the Research Laboratory of diseases with excessive calcification

Akkuratova str., 2, Saint Petersburg, 197341



M. L. Gordeev
Almazov National Medical Research Centre, World-Class Research Centre for Personalized Medicine
Russian Federation

Gordeev Mikhail L., Head of the Research Unit of Cardiothoracic Surgerz

Akkuratova str., 2, Saint Petersburg, 197341



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Review

For citations:


Filippov A.A., Uspenskiy V.E., Grubenko G.A., Тolpygin D.S., Karev E.A., Kvindt P.A., Ananyevskaya P.V., Kolodiazhnaya A.O., Malashicheva A.B., Gordeev M.L. EVALUATION OF STRUCTURAL FND FUNCTIONAL FEATURES OF REIMPLANTED AORTIC VALVE AFTER DAVID I PROCEDURE WITH THE USE OF HIGH-PRECISSION 3-DIMENSIONAL SEGMENTATION OF THE AORTIC ROOT. Russian Journal for Personalized Medicine. 2022;2(3):78-88. (In Russ.) https://doi.org/10.18705/2782-3806-2022-2-3-78-88

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ISSN 2782-3806 (Print)
ISSN 2782-3814 (Online)