Дизайн метаболомных исследований: преаналитический этап

Метаболомика — это комплексный анализ малых молекул, участвующих в метаболических путях, которые управляют биохимическими процессами и функциями клеток организма. Метаболомные исследования состоят из трех основных этапов: преаналитический, аналитический и постаналитический. В обзоре сделан акцент на важность преаналитического этапа, который представляет собой путь биообразца от пациента в биобанк и далее в аналитическую лабораторию. В обзоре на основе анализа литературных данных представлены факторы, которые влияют на качество образца и, следовательно, на качество конечного результата исследований: сбор клинической информации, выбор биоматрицы, сбор и обработка биообразцов и их последующее хранение. Правильный дизайн метаболомных исследований, контроль качества образцов от сбора до анализа физико-химическими методами обеспечивают получение данных, которые могут улучшить качество диагностики заболеваний, обеспечить переход к персонализированной медицине.

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